Novel mechanism of blocking axonal Na+ channels by three macrocyclic polyamine analogues and two spider toxins

British Journal of Pharmacology

Volumn 132, Issue 1, 2001, Pages 63-72

  Yakehiro, Masuhide ^a   Furukawa, Yasuo ^a   Koike, Tohru ^b   Kimura, Eiichi ^b   Nakajima, Terumi ^c   Yamaoka, Kaoru ^a   Seyama, Issei ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Block; Internal phase; JSTX 3; Macrocyclic polyamine; NSTX 3; Spider toxin

Indexed keywords

CYCLAM; CYCLAM DERIVATIVE; G CYCLAM; N 4; POLYAMINE DERIVATIVE; POTASSIUM CHANNEL; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SPIDER VENOM; SPIDER VENOM JSTX3; SPIDER VENOM NSTX3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; DRUG MECHANISM; HYDROPHOBICITY; NERVE FIBER MEMBRANE CONDUCTANCE; NONHUMAN; PRIORITY JOURNAL; SODIUM TRANSPORT; SQUID; VOLTAGE CLAMP;

EID: 0035142929     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703765     Document Type: Article

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