Relative fitness of carriers of the mitochondrial DNA mutation 3243A > G

European Journal of Human Genetics

Volumn 9, Issue 1, 2001, Pages 59-62

  Moilanen, J S ^a   Majamaa, K ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

MELAS syndrome; Mitochondrial encephalomyopathies; Net reproduction rate; Population genetics; Reproduction; Selection

Indexed keywords

ADENINE; GUANINE; LEUCINE TRANSFER RNA; MITOCHONDRIAL DNA;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FITNESS; GENDER; GENE MUTATION; GENETIC SELECTION; HETEROZYGOTE; HUMAN; MUTATION RATE; POINT MUTATION; POPULATION; PRIORITY JOURNAL; REPRODUCTION; STATISTICS; SURVIVAL; TECHNIQUE;

EID: 0035142916     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200550     Document Type: Article

References (16)

1. Mitochondrial disorders
2. Epidemiology of A3243G, the mutation for mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes: Prevalence of the mutation in an adult population
3. Increased prevalence of vitiligo, but no evidence of premature ageing, in the skin of patients with bp 3243 mutation in mitochondrial DNA in the mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS)
4. Family-genetic studies of psychiatric disorders. Developing technologies
5. New estimates of intergenerational time intervals for the calculation of age and origin of mutations
6. Relationship of genotype to phenotype in fibroblast-derived transmitochondrial cell lines carrying the 3243 mutation associated with the MELAS encephalomyopathy: Shift towards mutant genotype and role of mtDNA copy number
7. Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA
8. Evidence from human oocytes for a genetic bottleneck in an mtDNA disease