Distribution of Bcl-2 and Bax in embryonic and fetal human skin: Antiapoptotic and proapoptotic proteins are differentially expressed in developing skin

American Journal of Dermatopathology

Volumn 23, Issue 1, 2001, Pages 1-7

  Sellheyer, Klaus ^a,b,c   Krahl, Dieter ^a,b   Ratech, Howard ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Institut fur Dermatohistologie   (Germany)

^c MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Bax; Bcl 2; Embryology; Skin; Stem cells

Indexed keywords

GENE PRODUCT; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DENDRITIC CELL; EMBRYO; EPIDERMIS; FETUS; HAIR FOLLICLE; HAIR GROWTH; HAIR ROOT; HUMAN; HUMAN TISSUE; KERATINIZATION; MELANOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SKIN EPITHELIUM; SKIN FIBROBLAST; TRICHILEMMOMA;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; ECCRINE GLANDS; EMBRYO; GESTATIONAL AGE; HAIR FOLLICLE; HUMANS; IMMUNOENZYME TECHNIQUES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SKIN;

EID: 0035142309     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000372-200102000-00001     Document Type: Article

References (26)

1. Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death
2. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death
3. Expression of bcl-2 in fetal tissues suggests a role in morphogenesis
4. BCL-2 expression in adult and embryonic non-haematopoietic tissues
5. Aberrant bcl-2 protein expression provides a possible mechanism of neoplastic cell growth in cutaneous basal-cell carcinoma
6. Melanocytes in human skin express bcl-2 protein
7. Bcl-2 expression in melanocytic nevi. Insights into the biology of dermal maturation
8. Bcl-2 expression in epidermal keratinocytic diseases
9. Human melanocytes and melanoma cells constitutively express the bcl-2 protooncogene in situ and in cell culture
10. The expression and localization of bcl-2 protein in normal skin and in non-melanoma skin cancers
11. Expression of the apoptosis-suppressing protein Bcl-2 in non-melanoma skin cancer
12. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells
13. Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation
14. Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
15. Altered expression of bcl-2 family member proteins in nonmelanoma skin cancer
16. Expression of the bcl-2 homologue bax in normal human skin, psoriasis vulgaris and non-melanoma skin cancers
17. Differential expression of cell survival and cell cycle regulatory proteins in cutaneous squamoproliferative lesions
18. Altered expression of the p53-regulated proteins, p21 Waf/Cip1, MDM2, and bax in ultraviolet-irradiated human skin
19. High-intensity flashlamp photoepilation. A clinical, histologic, and mechanistic study in human skin
20. Immunoperoxidase technique modified by counterstain with azure B as a diagnostic aid in evaluating heavily pigmented melanocytic neoplasms
21. The dermal papilla and maintenance of hair growth
22. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
23. The anatomy of follicles producing wool-fibers, with special reference to keratinization
24. Structure and function of the developing human skin
25. The fine structure of developing human epidermis: Light, scanning, and transmission electron microscopy of the periderm
26. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair