Hydroxyurea-induced oxidative damage of normal and sickle cell hemoglobins in vitro: Amelioration by radical scavengers

Journal of Clinical Laboratory Analysis

Volumn 15, Issue 1, 2001, Pages 1-7

  Iyamu, Efe W ^a,c   Fasold, Hugo ^b   Roa, Dante ^a   Aguinaga, Maria Del Pilar ^a   Asakura, Toshio ^c   Turner, Ernest A ^a  

^a MEHARRY MEDICAL COLLEGE   (United States)

^b GOETHE UNIVERSITY   (Germany)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Anti oxidants; High performance liquid chromatography; Methemoglobin; Sickle cell anemia; Spectrophotometry

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; GLOBIN; HEME; HEMOGLOBIN A; HEMOGLOBIN F; HEMOGLOBIN S; HEMOGLOBIN VARIANT; HYDROGEN PEROXIDE; HYDROXYUREA; MANNITOL; METHEMOGLOBIN; SCAVENGER;

ADULT; ARTICLE; BLOOD SAMPLING; BONE MARROW SUPPRESSION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HEMOGLOBIN DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INCUBATION TIME; NEWBORN; OXIDATIVE STRESS; SICKLE CELL ANEMIA;

ADOLESCENT; ADULT; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; FETAL HEMOGLOBIN; FREE RADICAL SCAVENGERS; HEME; HEMOGLOBIN A; HEMOGLOBIN, SICKLE; HUMANS; HYDROGEN PEROXIDE; HYDROXYUREA; INFANT, NEWBORN; MANNITOL; METHEMOGLOBIN; OXIDATION-REDUCTION; SPECTROPHOTOMETRY;

LETHRINIDAE;

EID: 0035138865     PISSN: 08878013     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2825(2001)15:1<1::AID-JCLA1>3.0.CO;2-I     Document Type: Article

References (27)

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