Does intensive histopathological workup by serial sectioning increase the detection of lymph node micrometastasis in patients with primary cutaneous melanoma?

Melanoma Research

Volumn 11, Issue 1, 2001, Pages 57-63

  Blaheta, H J ^a   Sotlar, K ^a   Breuninger, H ^a   Bueltmann, B ^a   Rassner, G ^a   Garbe, C ^a   Horny, H P ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Immunohistochemistry; Lymph node micrometastasis; Melanoma; RT PCR; Step sections; Tyrosinase

Indexed keywords

EOSIN; HEMATOXYLIN; PROTEIN S 100;

ADULT; AGED; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; MELANOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SECTION; TUMOR CELL; TUMOR DIAGNOSIS; TUMOR RECURRENCE;

ADULT; AGED; COLORING AGENTS; EOSINE YELLOWISH-(YS); FEMALE; HEMATOXYLIN; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MELANOMA; MIDDLE AGED; MONOPHENOL MONOOXYGENASE; NEOPLASM PROTEINS; RECURRENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; S100 PROTEINS; SKIN NEOPLASMS; TIME FACTORS;

EID: 0035138157     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-200102000-00007     Document Type: Article

References (27)

1. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma
2. Efficacy of an elective regional lymph node dissection of 1 to 4 mm thick melanomas for patients 60 years of age and younger
3. Role of computed tomography in the staging of patients with local-regional metastases of melanoma
4. An analysis of prognostic factors in 8500 patients with cutaneous melanoma
5. Intraoperative lymphatic mapping and selective cervical lymphadenectomy for early-stage melanomas of the head and neck
6. Technical details of intraoperative lymphatic mapping for early stage melanoma
7. The orderly progression of melanoma nodal metastases
8. Patterns of recurrence following a negative sentinel lymph node biopsy in 243 patients with stage I or II melanoma
9. Occult tumor cells in the lymph nodes of patients with pathological stage I malignant melanoma. An immunohistological study
10. A103: An anti-Melan-A monoclonal antibody for the detection of malignant melanoma in paraffin-embedded tissues
11. Detection of microscopic melanoma metastases in sentinel lymph nodes
12. Lymph node micrometastases of cutaneous melanoma: Increased sensitivity of molecular diagnosis in comparison to immunohistochemistry
13. Detection of melanoma micrometastasis in sentinel nodes by RT-PCR correlates with tumor thickness and is predictive for micrometastatic disease in the lymph node basin
14. Detection of submicroscopic lymph node metastases with polymerase chain reaction in patients with malignant melanoma
15. Molecular test for the detection of tumor cells in blood and sentinel nodes of melanoma patients
16. Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus
17. Prognostic significance of occult metastases detected by sentinel lymphadenectomy and reverse transcriptase-polymerase chain reaction in early-stage melanoma patients
18. Molecular staging of malignant melanoma: Correlation with clinical outcome
19. Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction
20. Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene
21. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics
22. Classification of isolated tumor cells and micrometastasis
23. Melanoma-associated antigen recognized by T cells (MART-1) - The advent of a preferred immunocytochemical antibody for the diagnosis of metastatic malignant melanoma with fine-needle aspiration
24. Polymerase chain reaction and immunohistochemistry frequently detect occult melanoma cells in regional lymph nodes of melanoma patients
25. Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes
26. Optimal histopathologic examination of the sentinel lymph node for breast carcinoma staging
27. Benign melanocytic nevus cells in axillary lymph nodes. A prospective incidence and immunohistochemical study with literature review