New approach for accurate simulation of human pharmacokinetics in an in vitro pharmacodynamic model: Application to ciprofloxacin

Journal of Antimicrobial Chemotherapy

Volumn 47, Issue 2, 2001, Pages 223-227

  Ba, Boubakar B ^a   Bernard, Arnaud ^a   Iliadis, Athanassios ^b   Quentin, Claudine ^a   Ducint, Dominique ^a   Etienne, Renaud ^a   Fourtillan, Mathieu ^a   Maachi Guillot, Isabelle ^a   Saux, Marie Claude ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CAPILLARY; COMPUTER PROGRAM; COMPUTER SYSTEM; CONTROLLED STUDY; DEVICE; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEEDBACK SYSTEM; FLOW RATE; FLUID BALANCE; HUMAN; IN VITRO STUDY; INFUSION; KINETICS; MODEL; NONHUMAN; PERISTALTIC PUMP; PHARMACODYNAMICS; PHARMACOKINETICS; PLASMA; SIMULATION; TISSUE;

EID: 0035137309     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/47.2.223     Document Type: Article

References (10)

1. In vitro models for the study of antibiotic activities
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4. PHARMACOKIN: A software for pharmacokinetic teaching
5. Dose ranging study and constant infusion evaluation of ciprofloxacin
6. Pharmacokinetics and tissue penetration of ciprofloxacin
7. Computer-controlled in-vitro simulation of multiple dosing regimens
8. Distribution and antimicrobial activity of ciprofloxacin in human soft tissues
9. Penetration of ciprofloxacin into human lung tissue after oral and i.v. dosing
10. Pharmacokinetics and pharmacodynamics of intravenous ciprofloxacin. Studies in vivo and in an in vitro dynamic model