Stochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay

Mathematical Biosciences

Volumn 169, Issue 1, 2001, Pages 27-51

  Hyrien, Ollivier ^a   Klés, Virginie ^a   Concordet, Didier ^b   Bonneu, Michel ^c   Laurentie, Michel ^a   Sanders, Pascal ^a  

^a Healthy Pigs Production and Experimentation Section   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c UNIVERSITÉ TOULOUSE JEAN JAURÈS   (France)

Author keywords

Branching process; Erythropoietic system; Markovian process; Micronucleus assay; Non homogeneous birth and death process; Toxicokinetic

Indexed keywords

MERCAPTOPURINE; MUTAGENIC AGENT;

ANIMAL MODEL; ARTICLE; BONE MARROW TOXICITY; CELL DAMAGE; ERYTHROPOIESIS; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; NONHUMAN; STOCHASTIC MODEL; TOXICOKINETICS;

6-MERCAPTOPURINE; ANIMALS; ERYTHROPOIESIS; KINETICS; MARKOV CHAINS; MICE; MICRONUCLEUS TESTS; MODELS, BIOLOGICAL; MUTAGENS; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; STOCHASTIC PROCESSES;

EID: 0035136428     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0025-5564(00)00052-3     Document Type: Article

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