Antibody libraries in drug and target discovery

Drug Discovery Today

Volumn 6, Issue 1, 2001, Pages 36-43

  Rader, Christoph ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; MONOCLONAL ANTIBODY; RITUXIMAB; TRASTUZUMAB;

ANTIBODY LIBRARY; ANTIBODY STRUCTURE; BREAST CANCER; CANCER; CANCER THERAPY; CATALYSIS; DRUG DEVELOPMENT; HUMAN; HYBRIDOMA; NONHODGKIN LYMPHOMA; REVIEW; TECHNOLOGY;

EID: 0035135845     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(00)01595-6     Document Type: Review

References (76)

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4. Continuous culture of fused cells secreting antibody of predefined specificity
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6. Phage display of combinatorial antibody libraries
7. Filamentous fusion phage: novel expression vectors that display cloned antigens on the surface of the virion
8. Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces
9. Making antibody fragments using phage display libraries
10. Assembly of combinatorial antibody libraries on phage surfaces: the gene III site
11. A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals
12. By-passing immunization. Human antibodies from V-gene libraries displayed on phage
13. Biosynthetic polypeptide libraries
14. In vitro display technologies - new tools for drug discovery
15. Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries
16. Yeast surface display for screening combinatorial polypeptide libraries
17. Antibody affinity maturation using bacterial surface display
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19. Signaling antibodies in cancer therapy
20. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
21. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library
22. A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies
23. Exploiting recombination in single bacteria to make large phage antibody libraries
24. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides
25. Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries
26. Synthetic human antibodies
27. Designing and optimizing library selection strategies for generating high-affinity antibodies
28. Implications of the diversity of the immunoglobulin gene superfamily
29. In vitro evolution of a T cell receptor with high affinity for peptide/MHC
30. Directed evolution of a stable scaffold for T-cell receptor engineering
31. Design and expression of soluble CTLA-4 variable domain as a scaffold for the display of functional polypeptides
32. The fibronectin type III domain as a scaffold for novel binding proteins
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34. Directed evolution of new catalytic activity using the α/β-barrel scaffold
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36. CDR substitutions of a humanized monoclonal antibody (CC49): contributions of individual CDRs to antigen binding and immunogenicity
37. Replacing the complementarity-determining regions in a human antibody with those from a mouse
38. Reshaping human antibodies for therapy
39. Conformational correction mechanisms aiding antigen recognition by a humanized antibody
40. Antibody framework residues affecting the conformation of the hypervariable loops
41. Structural insights into the evolution of an antibody combining site
42. A combinatorial library strategy for the rapid humanization of anticarcinoma BR96 Fab
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45. Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen
46. A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries
47. Reconstructing aldolase antibodies to alter their substrate specificity and turnover
48. Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent
49. Generation and characterization of a recombinant human CCR5-specific antibody: a phage display approach for rabbit antibody humanization
50. Recombinant antibody constructs in cancer therapy
51. Generating improved single-chain Fv molecules for tumor targeting
52. Selection and evolution of high-affinity human anti-viral antibodies
53. Clonal selection and learning in the antibody system
54. Rapid evolution of a protein in vitro by DNA shuffling
55. Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity
56. In vitro evolution of a neutralizing human antibody to HIV-1 to enhance affinity and broaden strain cross-reactivity
57. CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range
58. Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site
59. Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues
60. Antibody arrays for high-throughput screening of antibody-antigen interactions
61. Opportunities at the interface of chemistry and biology
62. Making enzymes
63. Multiple event activation of a generic prodrug trigger by antibody catalysis
64. Catalytic antibodies as magic bullets
65. Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: primary amide bond hydrolysis
66. Evolving catalytic antibodies in a phage-displayed combinatorial library
67. Human neoplasms elicit multiple specific immune responses in the autologous host
68. Genes expressed in human tumor endothelium
69. Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library
70. Identification of a human anti-CD55 single-chain Fv by subtractive panning of a phage library using tumor and nontumor cell lines
71. Organ targeting in vivo using phage display peptide libraries
72. Membrane dipeptidase is the receptor for a lung-targeting peptide identified by in vivo phage display
73. In vivo selection of scFv from phage display libraries
74. Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells
75. Immune versus natural selection: antibody aldolases with enzymatic rates but broader scope