In vitro inhibition studies of phytoene desaturase by bleaching ketomorpholine derivatives

Journal of Agricultural and Food Chemistry

Volumn 49, Issue 1, 2001, Pages 138-141

  Sandmann, Gerhard ^a   Mitchell, Glynn ^b  

^a GOETHE UNIVERSITY   (Germany)

^b JEALOTT S HILL RESEARCH STATION   (United Kingdom)

Author keywords

Bleaching; Carotenoid biosynthesis; Herbicidal activity; Ketomorpholine; Phytoene desaturase inhibition

Indexed keywords

5 METHYL 2 (3 TRIFLUOROMETHYLBENZYL) 3 KETOMORPHOLINE; BLEACHING AGENT; CAROTENOID; ENZYME INHIBITOR; HERBICIDE; KETOMORPHOLINE DERIVATIVE; MORPHOLINE DERIVATIVE; OXIDOREDUCTASE; PHYTOENE; PHYTOENE DESATURASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME INACTIVATION; NONHUMAN; PHYTOENE DEHYDROGENASE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

CAROTENOIDS; ENZYME INHIBITORS; HERBICIDES; MORPHOLINES; OXIDOREDUCTASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035135773     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf0010432     Document Type: Article

References (4)

1. Böger, P.; Sandmann, G. Carotenoid biosynthesis inhibitor herbicides - mode of action and resistance mechanisms. Pestic. Outlook 1998, 9, 29-35.
2. Chamovitz, D.; Sandmann, G.; Hirschberg, J. Molecular and biochemical characterization of herbicide-resistant mutants of cyanobacteria reveals that phytoene desaturation is a rate-limiting step in carotenoid biosynthesis. J. Biol. Chem. 1993, 268, 17348-17353.
3. Sandmann, G.; Fraser, P. D. Differential inhibition of phytoene desaturase from diverse origins and analysis of resistant cyanobacterial mutants. Z. Naturforsch., C: J. Biosci. 1993, 48c, 307-311.
4. Martinez-Ferez, I.; Vioque, A.; Sandmann, G. Mutagenesis of an amino acid responsible in phytoene desaturase from Synechocystis for binding of the bleaching herbicide norflurazon. Pestic. Biochem. Physiol. 1994, 48, 185-190.