Behavioural, histological and immunocytochemical consequences following 192 IgG-saporin immunolesions of the basal forebrain cholinergic system

Brain Research Bulletin

Volumn 54, Issue 1, 2001, Pages 29-48

  Perry, TracyAnn ^a,b   Hodges, Helen ^a   Gray, Jeffrey A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Basal forebrain; Cholinergic system; Immunotoxin; Memory

Indexed keywords

CHOLINE ACETYLTRANSFERASE; IMMUNOTOXIN; NERVE GROWTH FACTOR RECEPTOR; SAPORIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DEAFFERENTATION; ENZYME ACTIVITY; FOREBRAIN; LEARNING; MALE; MAZE TEST; MEMORY; NONHUMAN; OLIVARY NUCLEUS; PERFORMANCE; PRIORITY JOURNAL; RAT; SEPTUM PELLUCIDUM;

ACETYLCHOLINESTERASE; ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; BEHAVIOR, ANIMAL; BIOLOGICAL MARKERS; CALCIUM; CELL COUNT; CEREBRAL CORTEX; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC AGENTS; CHOLINERGIC FIBERS; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOTOXINS; LOCOMOTION; MALE; MAZE LEARNING; MEMORY; N-GLYCOSYL HYDROLASES; NERVE DEGENERATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, NERVE GROWTH FACTOR; SEPTAL NUCLEI;

EID: 0035135572     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(00)00413-5     Document Type: Article

References (77)

1. Cholinergic system and memory in the rat; Effects of chronic ethanol, embryonic basal forebrain brain transplants and excitotoxic lesions of cholinergic basal forebrain projection system
2. Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse; An in situ hybridization study
3. Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain; Response to fimbria-fornix transection
4. Selective immunotoxic lesions of basal forebrain cholinergic cells; Effects on learning and memory in rats
5. Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input
6. Intact spatial learning following lesions of basal forebrain cholinergic neurons
7. Disruption of decrements in conditioned stimulus processing by selective removal of hippocampal cholinergic input
8. Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis
9. 192 IgG-saporin; I. Specific lethality for cholinergic neurons in the basal forebrain of the rat
10. Effects of unilateral removal of basal forebrain cholinergic neurons on cued target detection in rats
11. Basal forebrain cholinergic lesions disrupt increments but not decrements in conditioned stimulus processing
12. Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain
13. Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin
14. Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats
15. Cortical cholinergic fibers in aging and Alzheimer's disease; A morphometric study
16. Interactions between the effects of propranolol and nicotine on radial maze performance of rats with lesions of the forebrain cholinergic projection system
17. Place navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis
18. Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor
19. Lesions in nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments
20. The effect of magnocellular basal forebrain lesions on circadian locomotor activity in the rat
21. Improved radial maze performance induced by the benzodiazepine antagonist ZK 93 426 in lesioned and alcohol-treated rats
22. Cholinergic-rich transplants alleviate cognitive deficits in lesioned rats, but exacerbate response to cholinergic drugs
23. Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system-I. Amelioration of cognitive deficits by transplants into cortex and hippocampus but not into basal forebrain [published erratum appears in Neuroscience 1992;47(1):249]
24. Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system. II. Cholinergic drugs as probes to investigate lesion-induced deficits and transplant-induced functional recovery
25. The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats
26. Maze procedures; The radial-arm and water maze compared
27. The histochemical identification of acetylcholinesterase in cholinergic adrenergic and sensory organs
28. Differential regulation of the low-affinity nerve growth factor receptor during postnatal development of the rat brain
29. Selective lesioning of the basal forebrain cholinergic system by intraventricular 192 IgG-saporin; Behavioural, biochemical and stereological studies in the rat
30. Selective immunolesioning of the basal forebrain cholinergic system disrupts short-term memory in rats
31. Hippocampal theta activity following selective lesion of the septal cholinergic system
32. Co-localization of acetylcholinesterase and choline acetyltransferase in the rat cerebrum
33. Light and electron microscopic study of m2 muscarinic acetylcholine receptor in the basal forebrain of the rat
34. Analysis of galanin and the galanin antagonist M40 on delayed non-matching-to-position performance in rats lesioned with the cholinergic immunotoxin 192 IgG-saporin
35. Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain; Selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density
36. Selective immunolesions of hippocampal cholinergic input fail to impair spatial working memory
37. Attentional functions of the forebrain cholinergic systems; Effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task
38. AMPA-induced excitotoxic lesions of the basal forebrain; A significant role for the cortical cholinergic system in attentional function
39. Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system
40. Dissociable effects on spatial maze and passive avoidance acquisition and retention following AMPA- and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats; Differential dependence on cholinergic neuronal loss
41. Convergent cholinergic activities in aging and Alzheimer's disease
42. Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat; Further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes
43. Comparative effects of quisqualic and ibotenic acid-induced lesions of the substantia innominata and globus pallidus on the acquisition of a conditional visual discrimination; Differential effects on cholinergic mechanisms
44. Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease; Assessment of attentional and mnemonic function using CANTAB.
45. A comparison of the distribution of central cholinergic neurons as demonstrated by acetylcholinesterase pharmacohistochemistry and choline acetyltransferase immunohistochemistry
46. Intraseptal injections of 192 IgG saporin produce deficits for strategy selection in spatial-memory tasks
47. Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory
48. Cholinergic lesions by 192 IgG-saporin and short-term recognition memory; Role of the septohippocampal projection
49. The effects of selective cholinergic basal forebrain lesions and aging upon expectancy in the rat
50. Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system
51. Cortical acetylcholine and processing capacity; Effects of cortical cholinergic deafferentation on crossmodal divided attention in rats
52. Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin
53. 192 Immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells
54. Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats
55. Cholinergic receptor blockade in the rat impairs locale but not taxon strategies for place navigation in a swimming pool
56. Alzheimer's disease and senile dementia; Loss of neurons in the basal forebrain
57. Ibotenic acid lesions of the lateral hypothalamus; Comparison with the electrolytic lesion syndrome
58. Loss of nucleus basalis magnocellularis, but not septal cholinergic neurons correlates with passive avoidance impairment in rats treated with 192-saporin