The growth hormone-releasing hormone receptor: Desensitisation following short-term agonist exposure

Pharmacology and Toxicology

Volumn 88, Issue 2, 2001, Pages 81-88

  Hansen, Birgit Sehested ^a   Gerlach, Lars Ole ^a   Hansen, Annette ^a   Foged, Christian ^a   Andersen, Peter Hongaard ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; FORSKOLIN; GROWTH HORMONE RELEASING FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HYPOPHYSIS CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION;

ANIMALIA; CRICETINAE;

EID: 0035134790     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2001.088002081.x     Document Type: Article

References (5)

1. Aleppo, G., S.-F. Moskal, P.-A. Degrandis, R.-D. Kineman & L.-A. Frohman: Homologous down-regulation of growth hormone-releasing hormone-receptor messenger-ribonucleic-acid levels. Endocrinology 1997, 138, 1058-1065.
2. 2. Peptide and protein drug delivery. In: Alfred Benzon Symposium. Munksgaard, Copenhagen, Denmark 1998, pp. 50-60
3. Argente, J., J. Pozo & J.-A. Chowen: The growth hormone axis: control and effects. Hormone Res. 1996, 45, 9-11.
4. Bilezikjian, L.-M. & W.-W. Vale: Chronic exposure of cultured rat anterior pituitary cells to GRF causes partial loss of responsiveness to GRF. Endocrinology 1984, 115, 2032-2034.
5. Bilezikjian, L.-M., H. Seifert & W.-W. Vale: Desensitization to growth hormone-releasing factor (GRF) is associated with down-regulation of GRF-binding sites. Endocrinology 1986, 118, 2045-2052.