The effects of interferon alpha-2b in combination with ribavirin on health related quality of life and work productivity

Journal of Hepatology

Volumn 34, Issue 1, 2001, Pages 140-147

  McHutchison, John G ^a   Ware Jr , John E ^b,c,d,e   Bayliss, Martha S ^b,c   Pianko, Stephen ^a   Albrecht, Janice K ^f   Cort, Susannah ^f   Yang, Ilsoon ^f   Neary, Maureen P ^f  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b QualityMetric Incorporated   (United States)

^c Health Assessment Lab   (United States)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Combination therapy; Health related quality of life; Hepatitis C treatment; Hepatitis quality of life questionnaire; Interferon; Ribavirin; SF 36 health survey; Work productivity

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIVIRUS AGENT; REBETRON; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HEPATITIS C; HISTOLOGY; HUMAN; JOB PERFORMANCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VIRUS HEPATITIS; VIRUS LOAD;

ADULT; ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; DRUG THERAPY, COMBINATION; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2B; MALE; MIDDLE AGED; QUALITY OF LIFE; RECURRENCE; RIBAVIRIN;

EID: 0035133564     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)00026-X     Document Type: Article

References (36)

1. Epidemiology of hepatitis C
2. Clinical outcomes after transfusion-associated hepatitis C
3. Long-term mortality after transfusion-associated non-A, non-B hepatitis
4. Mortality from liver cancer and liver disease in hemophiliac men and boys in UK given blood products contaminated with hepatitis C
5. Liver transplantation for chronic viral hepatitis
6. Projecting the future healthcare burden from hepatitis C in the United States
7. A questionnaire to assess the generic and disease-specific health outcomes of patients with chronic hepatitis C
8. Health-related quality of life in chronic hepatitis C: Impact of disease and treatment response
9. Reduction of health-related quality of life in chronic hepatitis C and improvement with interferon therapy
10. Interferon alpha-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
11. Randomised trial of interferon alpha-2b plus ribavirin for 48 weeks or 24 weeks versus interferon alpha-2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus
12. The Medical Outcomes Study (MOS) 36item short-form health survey (SF-36): I. Conceptual framework and item selection
13. The Medical Outcomes Study (MOS) 36-item short-form health survey (SF-36): III. Tests of data quality, scaling assumptions and reliability across diverse patients groups
14. The Medical Outcomes Study (MOS) 36-item short-form health status survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs
15. Validating the SF-36 health survey questionnaire: New outcome measure for primary care
16. Comparative measurement sensitivity of short and longer health status instruments
17. The SF-36 Health survey questionnaire: An outcome measure suitable for routine use within the NHS?
18. Outcomes management in heart valve replacement surgery: Early experience
19. Patient-based health status measures in outpatient dialysis: Early experiences in developing an outcomes assessment program
20. Generic and disease-specific measures in assessing health status and HQL
21. Methods for assessing condition-specific and generic functional status outcomes after total knee replacement
22. A method for correcting item-total correlations for the effect of relevant item inclusion
23. Time-limit tests: Estimating their reliability and degree of speeding
24. Comparisons of the costs and quality of norms for the SF-36 Health Survey collected by mall versus telephone interview: Results from a national survey
25. The Beaver Dam health outcomes study: Initial catalog of health state quality factors
26. Differences in the mix of patients among medical specialties and systems of care: Results form the Medical Outcomes Study
27. Measuring functional status and well-being of patients with migraine headache
28. Advances in methods for assessing the impact of epilepsy and antiepileptic drug therapy on patients' health related HQL
29. Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis
30. Impaired health-related quality of life in chronic hepatitis C: The how, but not the why
31. SF-36 health survey annotated bibliography 2nd edition (1998-1996)