The role of oxygen-derived free radicals in augmented relaxations to levcromakalim in the aorta from hypertensive rats

Japanese Journal of Pharmacology

Volumn 85, Issue 1, 2001, Pages 29-33

  Kinoshita, H ^a   Kakutani, T ^a   Iranami, H ^a   Hatano, Y ^a  

^a JAPANESE RED CROSS WAKAYAMA MEDICAL CENTER   (Japan)

Author keywords

ATP sensitive K+ channel; Catalase; Glibenclamide; Hydrogen peroxide

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATALASE; DEFEROXAMINE; GLIBENCLAMIDE; HYDROGEN PEROXIDE; INDOMETACIN; LEMAKALIM; OXYGEN RADICAL; PEROXYNITRITE; PHENYLEPHRINE; POTASSIUM CHANNEL; SCAVENGER; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; HYPERTENSION; MALE; METABOLIC ACTIVATION; NONHUMAN; RAT; SMOOTH MUSCLE RELAXATION; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR RING; VASODILATATION;

EID: 0035133421     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.85.29     Document Type: Article

References (24)

1. Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite
2. Antioxidants inhibit ATP-sensitive potassium channels in cerebral arterioles
3. ATP channel by oxygen free radicals produced by xanthine oxidase reaction
4. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
5. The pharmacology of potassium channels and their therapeutic potential
6. + channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats
7. Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells
8. The role of endothelium-derived nitric oxide in relaxations to levcromakalim in the rat aorta
9. + channel openers
10. Physiological roles and properties of potassium channels in arterial smooth muscle
11. + channels in augmented relaxations to sodium nitroprusside induced by mexiletine in rat aortas
12. Exogenous tetrahydrobiopterin causes endothelium-dependent contractions in isolated canine basilar artery
13. Inhibition of tetrahydrobiopterin biosynthesis impairs endothelium-dependent relaxations in canine basilar artery
14. 1 cells
15. 2 in angiotensin II-induced vascular hypertrophy
16. Monocyte chemoattractant protein-1 expression in aortic tissues of hypertensive rats
17. Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats
18. Direct in situ measurement of nitric oxide in mesenteric resistance arteries - Increased decomposition by superoxide in hypertension
19. Superoxide anion production is increased in a model of genetic hypertension - Role of the endothelium
20. An ATP-sensitive potassium conductance in rabbit arterial endothelial cells
21. + channels in the cerebral microcirculation of genetically hypertensive rats - Evidence for their protection against cerebral vasospasm
22. + current in arterial membranes from genetically hypertensive rats
23. Gender difference in endothelial dysfunction in the aorta of spontaneously hypertensive rats
24. Impaired endothelium-dependent vasodilation in patients with essential hypertension: Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway