Lamivudine production via enantioselective deamination by thermostable Bacillus caldolyticus cytidine deaminase

Biotechnology Letters

Volumn 23, Issue 2, 2001, Pages 131-135

  Woo, Ju Hyung ^a   Shin, Hyun Jeung ^a   Kim, Tae Ho ^a   Ghim, Sa Youl ^a   Jeong, Lak Shin ^b   Kim, Jong Guk ^a   Song, Bang Ho ^a  

^a Kyungpook National University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

3TC; Bacillus caldolyticus; cdd; Cytidine deaminase; Lamivudine

Indexed keywords

1,3 OXATHIOLANE DERIVATIVE; 1,3 OXATHIOLANYLCYTOSINE; BACTERIAL ENZYME; CYTIDINE DEAMINASE; LAMIVUDINE; THIOURIDINE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACILLUS; BACILLUS CALDOLYTICUS; CHROMATOGRAPHY; DEAMINATION; ENANTIOMER; ENZYME PURIFICATION; ENZYME STABILITY; ESCHERICHIA COLI; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; STEREOCHEMISTRY; THERMOSTABILITY;

EID: 0035133244     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010353502346     Document Type: Article

References (10)

1. DNA replication and the division cycle in Escherichia coli
2. Asymmetric synthesis and biological evaluation ofβ-L-(2R,5S)- and α-L-(2R,5R)-1,3-oxathiolane-pyrimidine and purine nucle osides as potential anti-HIV agents
3. Advances in HIV/AIDS therapy
4. Profound suppression of hepatitis B virus replication with lamivudine
5. Enzymatic production of optically pure (2′R-cis)-2′-deoxy-3′-thiacytidine (3TC, Lamivudine): A potent anti-HIV agent
6. Antiretroviral therapy for HIV infection. A knowledge-based approach to drug selection and use
7. Lamivudine. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection
8. The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees)
9. Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase