Construction of the eukaryotic expression vector expressing the fusion protein of human endostatin protein and Il3 signal peptide

World Chinese Journal of Digestology

Volumn 9, Issue 1, 2001, Pages 43-46

  Cao, M M ^a   Pan, W ^a   Chen, Q L ^a   Ma, Z C ^a   Ni, Z J ^a   Wu, X L ^a   Wu, W B ^a   Pan, X ^a   Cao, G W ^a   Qi, Z T ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Endostatin; Eukaryotic expression vector; Gene amplification; Gene therapy; Polymerase chain reaction; Signal peptides

Indexed keywords

ENDOSTATIN; HYBRID PROTEIN; SIGNAL PEPTIDE;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; EUKARYOTIC CELL; EXPRESSION VECTOR; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; TUMOR GROWTH;

EID: 0035132813     PISSN: 10093079     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Angiogenesis and tumor metastasis
2. 121 in gastric carcinoma MGC803 cell line
3. Effect of intestinal ischemia-reperfusion on expressions of endogenous basic fibroblast growth factor and transforming growth factor β in lung and its relation with lung repair
4. bFGF and TGFβ expression in rat kidneys after ischemic/reperfusional gut injury and its relationship with tissue repair
5. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
6. Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin
7. Continuous administration of angiostatin inhibit accelerated growth of coloectal liver metastases after partial hepatectomy
8. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin
9. The rationale and future potential of angiogenesis inhibitors in neoplasia
10. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
11. The promise of anti-angiogenic cancer therapy
12. Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases
13. Antiangiogenic gene therapy
14. Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA
15. Targeting chemo-therapy: A new focus in gene therapy vesearch
16. Therapeutic potentials of angiostatin in the treatment of cancer
17. Molecular cloning and sequencing of endostatin cDNA derived from Chinese fetus hepatocytes
18. Induction of angingenesis during the transition from hyperplasia
19. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
20. Quantitative microvessel density. A staging and prognostic marker for human prostatic carcinoma
21. Tumor angiogenesis in human lung adenocarcinoma
22. Prognostic significance of tumoral angiogenesis in completely resected late stage lung carcinoma (stage III A-N2): Impact of adjuvant therapies in a subset of patients at high risk of recurrence
23. Tumor angiogenesis as a predictor of recurrence in gastric carcinoma
24. Tumor angiogenesis as a prognostic factor in cervical carcinoma
25. Tumor angiogenesis in advanced stage ovarian carcinoma
26. Intratumoral microvessel density and p53 protein: Correlation with metastasis in head-and-neck squamous-cell carcinoma
27. Anti-angiogenesis: New concept for therapy of solid tumors
28. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
29. The expression of platelet-derived growth factor and angiogenesis in human colorectal carcinoma
30. Effects of angiogenesis inhibitor TNP - 470 with lipiodol in arterial embolization of liver cancer in rabbit model
31. Gro-beta, a-C-X-C-chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice
32. The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis
33. Angiostatin: An endogenous inhibitor of angiogenesis and of tumor growth
34. Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation
35. Angiostatin binds ATP synthase on the surface of human endothelial cells
36. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
37. Structure, function and tissue forms of the C-terminal globular domain of collagen X VIII containing the angiogenesis inhibitor endostatin
38. Endostatin inhibits microvessel formation in the ex vivo rat aortic ring angiogenesis assay
39. Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene
40. Endostatin induces endothelial cell apoptosis
41. Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases
42. Synergy between angiostatin and endostatin: Inhibition of ovarian cancer growth
43. Antitumor activity of endostatin against carcinogen-induced rat primary mammary tumors
44. Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice
45. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
46. Cloning, expression, and in vitro activity of human endostatin
47. Inhibitory effect of full-length human endostatin on in vitro angiogenesis
48. Novel glycosylated forms of human plasma endostatin and circulating endostatin-related fragments of collagen X V
49. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity
50. Parenteral gene therapy with p53 inhibits human breast tumors in vivo through a bystander mechanism without evidence of toxicity
51. Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice