From peptide libraries to optimized nonpeptide ligands in the search for S-farnesyltransferase inhibitors

Journal of Peptide Research

Volumn 57, Issue 2, 2001, Pages 85-96

  Henlin, J M ^a   Kucharczyk, N ^a   Desmet Beaufort, C ^a   Loynel, A ^a   Genton, A ^a   Tucker, G C ^a   Atassi, G ^a   Fauchere J L ^a   Boutin, J A ^b   Bertrand, M ^c  

^a INSTITUT DE RECHERCHES SERVIER   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c NONE

Author keywords

Combinatorial chemistry; Deconvolution; Parallel synthesis; Peptide libraries; Peptide optimization; Pseudopeptides; S farnesyltransferase; Solid phase synthesis

Indexed keywords

ALANINE DERIVATIVE; AMINO ACID; HISTIDINE; PEPTIDE LIBRARY; PHENYLALANINE; PRODRUG; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PSEUDOPEPTIDE; TETRAPEPTIDE; TRYPTOPHAN;

ARTICLE; CHEMICAL MODIFICATION; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE;

ALKYL AND ARYL TRANSFERASES; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; LIGANDS; PEPTIDE LIBRARY; PEPTIDES;

EID: 0035132273     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2001.00787.x     Document Type: Article

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