Interaction of L-tryptophan with α-cyclodextrin: Studies with calorimetry and proton nuclear magnetic resonance spectroscopy

Journal of Pharmaceutical Sciences

Volumn 90, Issue 2, 2001, Pages 134-140

  Nishijo, Juziro ^a   Tsuchitani, Michiko ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

1H NMR; Conformational change; L tryptophan; Thermodynamic parameter; cyclodextrin

Indexed keywords

ALPHA CYCLODEXTRIN; PHOSPHATE; TRYPTOPHAN;

ARTICLE; CALORIMETRY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DISPERSION; HYDROGEN BOND; HYDROPHOBICITY; NUCLEAR OVERHAUSER EFFECT; PH; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPERATURE; THERMODYNAMICS;

EID: 0035131473     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200102)90:2<134::AID-JPS4>3.0.CO;2-T     Document Type: Article

References (15)

1. Use of 2-hydroxypropyl-β-cyclodextrin as a solubilizing and stabilizing excipient for protein drugs
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3. Nuclear magnetic resonance spectroscopy of amino acids, peptides, and proteins
4. 1H-NMR study of the inclusion of aromatic molecules in α-cyclodextrin
5. On the atomic or "local" contributions to chemical shifts due to the anisotropy of the diamagnetic susceptibility of the aromatic side chain of the amino acids and of the porphyrin ring
6. A nonlinear least squares program based on differential equation, MULTI(RUNGE), for microcomputers
7. Thermodynamics of the inclusion of cyclodextrins with aromatic and α-, φ-amino acids in aqueous solution
8. Thermodynamics of binding of aromatic amino acids to α-, β-, and γ-cyclodextrins
9. Thermodynamics of binding of guest molecules to α- and β-cyclodextrins
10. Improved component vicinal coupling constants for calculating side-chain conformations in aromatic acids
11. Nuclear magnetic resonance study of some α-amino acids-II. Rotational isomerism
12. 13C- NMR studies of formation and molecular dynamics of methylated -cyclodextrin inclusion complexes with phenylalanine
13. Conformation analysis of tryptophan in solution using nuclear magnetic resonance methods
14. Mechanism of the cycloamylose-accelerated cleavage of phenyl esters