Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels

British Journal of Pharmacology

Volumn 132, Issue 2, 2001, Pages 587-595

  Lapied, Bruno ^a   Grolleau, Françoise ^a   Sattelle, David B ^b  

^a UNIVERSITÉ D'ANGERS   (France)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

DUM neurones; Insect; Insecticide; Local anaesthetic; Neuronal sodium channels; Oxadiazine

Indexed keywords

INDOXACARB; INSECTICIDE; OXADIAZOLE DERIVATIVE; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; HYPERPOLARIZATION; INSECT; MEMBRANE STEADY POTENTIAL; MOTOR NERVE; NERVE CONDUCTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR BLOCKING; SODIUM CONDUCTANCE; SODIUM CURRENT; VOLTAGE CLAMP;

EID: 0035129476     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703853     Document Type: Article

References (38)

1. Lidocaine block of cardiac sodium channels
2. Natural and synthetic toxins at insect receptors and ion channels: The search for insecticide leads and target sites
3. Neuroreceptor mechanisms in pyrethroïd mode of action and resistance
4. Ion channels as targets for insecticides
5. + channels: Local anesthetics, antiarrhythmics and anticonvulsants
6. Synthetic pyrethroïds
7. Two classes of pyrethroïd action in the cockroach
8. Sodium channels as targets for neurotoxins: Mode of action and interaction of neurotoxins with receptor sites on sodium channels
9. Separation and identification of multiple potassium currents regulating the pacemaker activity of insect neurosecretory cells (DUM neurons)
10. 2+ currents contribute to the pacemaker mechanism in cockroach dorsal unpaired median neurons
11. Dorsal unpaired median neurones in the insect central nervous system: Towards a better understanding of the ionic mechanisms underlying spontaneous electrical activity
12. Improved patch-clamp technique for high resolution current recording from cells and cell-free membrane patches
13. Local anesthetics: Hydrophobic and hydrophilic pathways for the drug-receptor reaction
14. Blockade of the voltage-dependent sodium current in isolated rat hippocampal neurons by tetrodotoxin and lidocaine
15. Ionic species involved in the electrical activity of single aminergic neurones isolated from the sixth abdominal ganglion of the cockroach Periplaneta americana
16. Patch-clamp study of the properties of the sodium current in cockroach single isolated adult aminergic neurones
17. Biophysical properties of scorpion α-toxin-sensitive background sodium channel contributing to the pacemaker activity in insect neurosecretory cells (DUM neurons)
18. Mutations in the house fly Vssc1 sodium channel gene associated with super-kdr resistance abolish the pyrethroid sensitivity of Vssc1/tipE sodium channels expressed in Xenopus oocytes
19. Suppression of voltage-gated sodium currents by the dihydropyrazole insecticide DPX-JW062 in rat dorsal root ganglion neurons
20. Neuronal ion channels as the target sites of insecticides
21. Neuroreceptors and ion channels as the basis for drug action: Past, present and future
22. Ion channels as targets for insecticides
23. Biochemistry and genetics of insecticide resistance
24. Pharmacological properties of insect axons: A review
25. Anti-insect scorpion toxins: Historical account, activities and prospects
26. Mode of action of insecticidal dihydropyrazoles: Selective block of impulse generation in sensory nerves
27. Slow voltage-dependent block of sodium channels in crayfish nerve by dihydropyrazole insecticides
28. Molecular targets of pyrethroïd insecticides
29. Unusual response of DDT-resistant houseflies to carbinol analogues of DDT
30. Neurotoxic actions of pyrethroid insecticides
31. The kinetic basis for phasic local anesthetic blockade of neuronal sodium channels
32. Electrical recordings from cloned sodium channels expressed in Xenopus oocytes
33. Distinctly different rates of benzocaine action on sodium channels of Ranvier nodes kept open by chloramine-T and veratridine
34. Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons
35. Identification of mutations in the houseflyes para-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroïd insecticides
36. A novel oxadiazine insecticide is bioactivated in lepidopteran larvae
37. The insect voltage-gated sodium channel as target of insecticides