Donor lymphocyte infusion followed by interferon-α plus low dose cyclosporine A for modulation of donor CD3 cells activity with monitoring of minimal residual disease and cellular chimerism in a patient with first hematologic relapse of chronic myelogenous leukemia after allogeneic bone marrow transplantation

Leukemia Research

Volumn 25, Issue 4, 2001, Pages 353-357

  Leda, Michal ^a   Ladon, Dariusz ^b   Pieczonka, Anna ^a   Boruczkowski, Dariusz ^a   Jólkowska, Justyna ^b   Witt, Michal ^b   Wachowiak, Jacek ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b INSTITUTE OF HUMAN GENETICS   (Poland)

Author keywords

Allogeneic bone marrow transplantation; Cellular chimerism; Chronic myelogenous leukemia; Donor lymphocyte infusion; Genetic monitoring; Interferon ; Leukemia relapse; Minimal residual disease

Indexed keywords

ALPHA INTERFERON; BUSULFAN; CD3 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROXYUREA; LEUKOCYTE ANTIGEN; METHOTREXATE;

ADOLESCENT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; BONE MARROW SUPPRESSION; CASE REPORT; CHIMERA; CHRONIC MYELOID LEUKEMIA; CYTOGENETICS; DONOR; ECOTROPIC VIRUS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOPOIESIS; HUMAN; INFUSION; LYMPHOCYTE; MINIMAL RESIDUAL DISEASE; PANCYTOPENIA; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; RELAPSE; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; Y CHROMOSOME;

ADOLESCENT; ANTIGENS, CD3; BONE MARROW TRANSPLANTATION; CYCLOSPORINE; FEMALE; GRAFT VS LEUKEMIA EFFECT; HUMANS; INTERFERON-ALPHA; LEUKEMIA, MYELOID, CHRONIC; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; LYMPHOCYTE TRANSFUSION; NEOPLASM, RESIDUAL; RECURRENCE; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS;

EID: 0035127558     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(00)00143-0     Document Type: Article

References (10)

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4. G-CSF stimulated donor peripheral blood infusions as immunotherapy in patients with haematologic malignancies relapsing after allogeneic transplantation
5. Management of relapse
6. The interferons-mechanism of action and clinical aplications
7. Interferon alpha for chronic myeloid leukemia relapsing after allogeneic bone marrow transplantation
8. Lymphoblastoid human interferon and low dose IL-2 combined with donor lymphocyte infusion as therapy of a third relapse of CML - a case report
9. Successful treatment of relapsed CML after cord blood transplantation with donor leukocyte infusion, IL-2 and INFα