Insulin and heparin suppress superoxide production in diabetic rat glomeruli stimulated with low-density lipoprotein

Kidney International, Supplement

Volumn 59, Issue 78, 2001, Pages

  Chen, H C ^a   Guh, J Y ^a   Shin, S J ^a   Tsai, J H ^a   Lai, Y H ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Atherosclerosis; Diabetic nephropathy; Glomerular injury; Glomerulosclerosis; Hyperlipidemia; Oxygen free radicals

Indexed keywords

HEPARIN; INSULIN; LOW DENSITY LIPOPROTEIN; OXYGEN RADICAL; STREPTOZOCIN; SUPEROXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL PROTECTION; CELL STIMULATION; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; GLOMERULOSCLEROSIS; GLOMERULUS; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; ARTICLE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; IN VITRO STUDY; METABOLISM; WISTAR RAT;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; HEPARIN; INSULIN; KIDNEY GLOMERULUS; LIPOPROTEINS, LDL; MALE; RATS; RATS, WISTAR; SUPEROXIDES;

EID: 0035125418     PISSN: 00986577     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.59780124.x     Document Type: Conference Paper

References (17)

1. Focal and segmental glomerulosclerosis: Analogies to atheroselerosis
2. Autoantibody against oxidized LDL and progression of carotid atherosclerosis
3. Influence of density, impaired glucose tolerance and NIDDM on LDL structure and composition: Possible link between hyperinsulinemia and atherosclerosis
4. Cholesterol-lowering therapy may retard the progression of diabetic nephropathy
5. Increased oxidizability of plasma lipoproteins in diabetic patients can be decreased by probucol therapy and is not due to glycation
6. Lipid advanced glycosylation: Pathway for lipid oxidation in vivo
7. 125I-insulin by renal glomeruli and tubules isolated from rats
8. Regulation of heparin binding-epidermal growth factor like growth factor gene expression by LDL and oxidized-LDL in rat mesangial cells
9. Recombinant human erythropoietin enhances superoxide production of FMLP-stimulated leukocytes in hemodialysis patients
10. Susceptibility of low- and high-density lipoproteins from diabetic subjects to in vitro oxidative modification
11. Preferential binding of oxidized LDL to rat glomeruli in vivo and cultured mesangial cells in vitro
12. Native and oxidized low density lipoproteins modulate mesangial cell apoptosis
13. Possible relevance of lipid peroxidation and thromboxane production to the initiation and/or evolution of microangiopathy in non-hyperlipidemic type 2 diabetes mellitus
14. Insulin receptors of isolated glomeruli
15. Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy
16. Inhibition of mitogenesis and c-fos induction in mesangial cells by heparin and heparan sulfate
17. Characterisation of the binding of low-density lipoproteins to cultured rat mesangial cells