Mixed pharmacokinetic population study and diffusion model to describe ciprofloxacin lung concentrations

Computers in Biology and Medicine

Volumn 31, Issue 3, 2001, Pages 147-155

  Breilh, Dominique ^a,e   Saux, Marie Claude ^a   Maire, Pascal ^b   Vergnaud, Jean Maurice ^c   W Jelliffe, Roger ^d  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b Hopital Geriatrique Antoine Charial   (France)

^c UNIVERSITÉ JEAN MONNET   (France)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e HAUT LÉVÊQUE HOSPITAL   (France)

Author keywords

Ciprofloxacin; Lung diffusion; NONMEM; Population modeling

Indexed keywords

CIPROFLOXACIN; CREATININE;

ADULT; AGED; ARTICLE; BRONCHUS TUMOR; CLINICAL ARTICLE; COMPARTMENT MODEL; CREATININE BLOOD LEVEL; DIFFUSION; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RESEARCH; DRUG TISSUE LEVEL; DRUG TRANSPORT; EPITHELIUM TUMOR; FEMALE; HUMAN; LUNG; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; SIMULATION; STEADY STATE; TIME;

EID: 0035125332     PISSN: 00104825     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-4825(00)00031-7     Document Type: Article

References (20)

1. Clinical efficacy of ciprofloxacin in lower respiratory tract infections
2. Comparative study of pharmacokinetics and serum bactericidal activities of cefpirome, ceftazidime, ceftriaxone, imipeneme and ciprofloxacin
3. Pharmacokinetics of ciprofloxacin: Intravenous and increasing oral doses
4. Pharmacokinetics of ciprofloxacin after oral and parenteral administration
5. Comparative pharmacokinetics and safety of ciprofloxacin 400 mg IV thrice daily versus 750 mg PO twice daily
6. Increased oral bioavailability of ciprofloxacin in cystic fibrosis patients
7. Extravascular penetration of ciprofloxacin
8. Pharmacokinetics and tissue penetration of ciprofloxacin
9. Tissue penetration of ciprofloxacin after single and multiple doses
10. The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma and pleural tissue after intravenous administration
11. Penetration of ciprofloxacin and metabolites into human lung, bronchial and pleural tissue after 250 and 500 mg oral ciprofloxacin
12. The distribution of ciprofloxacin and its metabolites in human plasma, pulmonary and bronchial tissues
13. Concentration of ciprofloxacin in human serum, lung and pleural tissues and fluids during and after lung surgery
14. Penetration of pefloxacin and ciprofloxacin into lung tissue
15. Comparative pharmacokinetic disposition of fluoroquinolones in the lung
16. Pharmacokinetics of four fluoroquinolones in an animal model of infected lung
17. Comparative penetration of selected fluoroquinolones into respiratory tract fluids and tissues
18. Calculation of blood level of the drugs taken orally with a diffusion controlled dosage form
19. Prediction of in vivo blood level with controlled release dosage form. Effect of the gastro-intestinal tract time