Influence of water on the solubility of two steroid drugs in hydrofluoroalkane (HFA) propellants

Drug Development and Industrial Pharmacy

Volumn 27, Issue 1, 2001, Pages 71-79

  Williams III, R O ^a   Hu, C ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Drug solubility; HFA propellants; PMDI formulations

Indexed keywords

APAFLURANE; DYMEL; FLUORINATED HYDROCARBON; NORFLURANE; PROPELLANT; STEROID; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CALCULATION; CRYSTALLIZATION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG SYNTHESIS; HYDROPHOBICITY; TEMPERATURE SENSITIVITY; WATER CONTENT; X RAY DIFFRACTION;

AEROSOL PROPELLANTS; BECLOMETHASONE; GLUCOCORTICOIDS; HYDROCARBONS, FLUORINATED; SOLUBILITY; TEMPERATURE; TRIAMCINOLONE ACETONIDE; WATER;

EID: 0035123376     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-100000130     Document Type: Article

References (24)

1. Aerosol Formulation, Generation, and Delivery Using Metered Systems
2. Chemical Stability in Pressurized Inhalers Formulated as Solutions
3. Surfactant Promoted Crystal Growth of Micronized Methylprednisolone in Trichloromonofluoromethane
4. Axial Ratio Measurements for Early Detection of Crystal Growth in Suspension-Type Metered Dose Inhalers
5. Crystal Growth of Micronized Methylprednisolone in Trichloromonofluoromethane
6. Experimental Method for Studying Growth Rates of Particles in Aqueous Media
7. Accelerated Crystal Growth of Sulfathiazole by Temperature Cycling
8. Rate of Crystal Growth of Sulfathiazol and Methylpredinisolone
9. Inhibition of Sulfathiazole Crystal Growth by Polyvinylpyrrolidone
10. Determination of Drug Solubility in Aerosol Propellants
11. The Effects of Water in Inhalation Suspension Aerosol Formulations
12. Metered Dose Inhaler CFC Under Pressure
13. CFC Propellant Substitution: P-134a as a Potential Replacement for P-12 in MDI
14. Pharmaceutical Aerosols
15. Some Aspects of Alternative Propellant Solvency
16. Moisture Uptake and Its Influence on Pressurized Metered Dose Inhalers
17. Moisture-Solid Dosage Forms
18. Moisture in Pharmaceutical Products
19. Water Vapor Sorption Studies on the Physical Stability of a Series of Spray-Dried Protein/Sugar Powders for Inhalation
20. Thermodynamic Analysis of Moisture Sorption Isotherms
21. The Molecular Basis of Moisture Effects on the Physical and Chemical Stability of Drugs in the Solid State
22. Model for Moisture Transport into Inhalation Aerosols
23. Surfactant Association and Water Uptake in a Model Chlorofluorocarbon System
24. The Influence of the Particle Size on the Bioavailability of Inhaled Temazepam