Anti-thrombotic and haemorrhagic effects of active site-inhibited factor VIIa in rats

British Journal of Haematology

Volumn 112, Issue 2, 2001, Pages 506-512

  Ghrib, F ^a   Leger P ^a   Ezban, M ^b   Kristensen, A T ^b   Cambus, J P ^a   Boneu, B ^a  

^a CHU PURPAN   (France)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Active site inhibited factor VIIa; Anti thrombotic drug; Bleeding time; Thrombosis; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 7A; HEPARIN; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTERY BYPASS; ARTERY OCCLUSION; ARTICLE; BLEEDING; BLEEDING TIME; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYME INHIBITION; FEMALE; HEPARINIZATION; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOSIS;

ANIMALS; BLEEDING TIME; BLOOD PLATELETS; FACTOR VIIA; FIBRIN; FIBRINOLYTIC AGENTS; HEMORRHAGE; MALE; MODELS, ANIMAL; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; THROMBOPLASTIN; THROMBOSIS;

EID: 0035122836     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02570.x     Document Type: Article

References (25)

1. Prevention of experimental arterial thrombosis by topical administration of active site inactivated factor VIIa
2. The role of tissue factor in the pathogenesis of thrombosis and atherosclerosis
3. Fibrin-rich and platelet-rich thrombus formation on neointima: Recombinant tissue factor pathway inhibitor prevents fibrin formation and neointimal development following repeated balloon injury of rabbit aorta
4. Local inhibition of tissue factor reduces the thrombogenecity of disrupted human atherosclerotic plaques. Effects of tissue factor pathway inhibitor on plaque thrombogenieity under flow conditions
5. Tissue factor pathway inhibitor
6. Bleeding time in rats: A comparison of different experimental conditions
7. Selective cellular expression of tissue factor in human tissues
8. Inactivated factor VII, a new anti-thrombotic treatment: Results from healthy volunteers
9. Experimental thrombosis on a collagen coated arterioarterial shunt in rats: A pharmacological model to study anti-thrombotic agents inhibiting thrombin formation and platelet deposition
10. Anti-thrombotic effects of recombinant human, active-site blocked factor VIIa in a rabbit model of recurrent arterial thrombosis
11. Dissociation of anti-thrombotic effect and bleeding time prolongation in rabbits by inhibition tissue factor function
12. Local application of recombinant active site-inhibited human clotting factor VIIa reduces thrombus weight and improves patency in a rabbit venous thrombosis model
13. Influence of blockade at specific levels of the coagulation cascade on restenosis in a rabbit atherosderotic femoral artery injury model
14. The effect of escalating dosages of active site inhibited factor VII tF VIIai) and the effect of simultaneous administration of FFR-FVIIai (FFR) and heparin on bleeding in rabbits
15. Comparison of the anti-thrombotic effect of heparin, hirudin and dopidogrel according to the nature of thrombogenic surface in an arterioarterial shunt in rats
16. Biochemistry and physiology, of blood coagulation
17. Tissue factor induced coagulation triggers platelet thrombus formation as efficiently as fibrillar collagen at arterial blood flow conditions
18. A monoclonal antibody against rabbit tissue factor inhibits thrombus formation in stenotic injured rabbit carotid arteries
19. Incorporation of an active site inhibitor in factor VIIa alters the affinity to tissue factor
20. Tissue factor in the pathogenesis of atherosclerosis
21. Regulation of the procoagulant response to arterial injury
22. Active site inhibited factor VIIa (DEGR VIIa) attenuates the coagulant and interleukin-6 and -8, but not tumor necrosis factor responses of the baboon to LD1O0 Esherichia
23. Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells
24. In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X
25. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque