Inviting leukemic cells to waltz with the devil

Nature Medicine

Volumn 7, Issue 2, 2001, Pages 156-157

  Melo, J V ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; HYBRID PROTEIN; ONCOPROTEIN; PROTEIN ABL1; UNCLASSIFIED DRUG;

CHROMOSOME 22Q; CHROMOSOME 9; CHRONIC MYELOID LEUKEMIA; GENE REARRANGEMENT; HUMAN; HUMAN CELL; LEUKEMIA CELL; PHENOTYPE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; SHORT SURVEY;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELL NUCLEUS; ENZYME INHIBITORS; FATTY ACIDS, UNSATURATED; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA, MYELOID, CHRONIC; PIPERAZINES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; TUMOR CELLS, CULTURED;

EID: 0035122436     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/84591     Document Type: Short Survey

References (11)

1. A minute chromosome in human chronic granulocytic leukemia
2. The molecular biology of chronic myeloid leukemia
3. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
4. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
5. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL positive cells
6. In vivo eradication of human BCR/ABL positive leukemia cells with an ABL kinase inhibitor
7. Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase
8. The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products
9. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase
10. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport
11. Cycling, stressed-out and nervous: Cellular functions of c-Abl