Potent antitumor effects of intra-arterial injection of fibroblasts genetically engineered to express IL-12 in liver metastasis model of rat: No additional benefit of using retroviral producer cell

Cancer Gene Therapy

Volumn 8, Issue 1, 2001, Pages 17-22

  Iwazawa, Takashi ^a   Chau, Gar Yang ^a   Mori, Takahiro ^a   Dookeran, Keith A ^a   Rubin, Joshua T ^a   Watkins, Simon ^b   Robbins, Paul D ^b   Lotze, Michael T ^a   Tahara, Hideaki ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

CRIP cell; Fibroblast; Gene therapy; IL 12; Intra arterial injection; Liver tumor

Indexed keywords

INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FIBROBLAST; GENETIC ENGINEERING; HEPATIC ARTERY; LIVER METASTASIS; LIVER WEIGHT; MARKER GENE; NONHUMAN; PRIORITY JOURNAL; RAT; RETROVIRUS;

ANIMALIA; MARTES PENNANTI; UNIDENTIFIED RETROVIRUS;

EID: 0035121703     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700272     Document Type: Article

References (25)

1. Antitumor and antimetastatic activity of interleukin-12 against murine tumors
2. Recombinant IL-12 administration induces tumor regression in association with IFN-g production
3. Phase I evaluation of intravenous recombinant human interleukin-12 (rhIL-12) in patients with advanced malignancies
4. Fibroblasts genetically engineered to secrete interleukin-12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo
5. Cancer immunotherapy of established tumors with IL-12
6. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector
7. Clinical protocol; IL-12 gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts
8. Blood supply of neoplasms in the liver
9. Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic ranges
10. The use of beta-galactosidase as a tracer in immunocytochemistry
11. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
12. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
13. Characterization of a factor(s) which synergizes with recombinant interleukin-2 in promoting allogeneic human cytolytic T-lymphocyte responses in vitro
14. Induction of interferon-g production by natural killer cell stimulatory factor: Characterization of the responder cells and synergy with other inducers
15. + NK cells
16. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)
17. + T cells through IL-12 produced by listeria-induced macrophages
18. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-g in vivo
19. Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors
20. Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma
21. Gene gun-mediated skin transfection with interleukin-12 gene results in regression of established primary and metastatic murine tumors
22. Amount of interleukin 12 available at the tumor site is critical for tumor regression
23. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats
24. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
25. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells