The efficacy of nafamostat mesilate on the performance of a hybrid-artificial liver using a polyurethane foam/porcine hepatocyte spheroid culture system in human plasma

International Journal of Artificial Organs

Volumn 24, Issue 1, 2001, Pages 34-40

  Yamashita, Y ^a   Shimada, M ^a   Tsujita, E ^a   Rikimaru, T ^a   Ijima, H ^a   Nakazawa, K ^a   Sakiyama, R ^a   Fukuda, J ^a   Funatsu, K ^a   Sugimachi, K ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Human plasma; Hybrid artificial liver; Nafamostat mesilate (FUT); Porcine hepatocyte; Spheroids; Xenoimmunologic reaction

Indexed keywords

AMINO ACIDS; AMMONIA; DETOXIFICATION; PACKED BEDS; PLASMA (HUMAN); POLYURETHANES; RIGID FOAMED PLASTICS;

ARTIFICIAL LIVER; HEPATOCYTE/SPHEROID; HEPATOCYTES; HUMAN PLASMAS; HYBRID-ARTIFICIAL LIVER; NAFAMOSTAT MESILATE (FUT); POLYURETHANE FOAM; PORCINE HEPATOCYTE; SPHEROID; XENOIMMUNOLOGIC REACTION;

ARTIFICIAL ORGANS;

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; AMMONIA; NAFAMSTAT MESILATE; POLYURETHAN FOAM;

ANIMAL CELL; ARTICLE; ARTIFICIAL LIVER; BIOMEDICAL TECHNOLOGY ASSESSMENT; COMPLEMENT ACTIVATION; DETOXIFICATION; HUMAN; HYBRID; IMMUNOREACTIVITY; LIVER CELL; LIVER CELL CULTURE; NONHUMAN; PLASMA; PROTEINASE INHIBITION; SPHEROID CELL; SWINE;

EID: 0035119349     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880102400107     Document Type: Article

References (23)

1. Fulminant liver failure: Relevance of extra corporeal hybrid liver support systems
2. Artificial liver: Evolution and perspectives
3. Clinical experience with a bioartificial liver in the treatment of severe liver failure: A phase I clinical study
4. Development of a hybrid liver support system: A review
5. Hepatocyte spheroids in polyurethane forms: Functional analysis and application for a hybrid artificial liver
6. Evaluation of a hybrid artificial liver using a polyurethane foam packed-bed culture system in dogs
7. Development of hybrid artificial liver support system using spheroid culture and application to warm ischemic liver failure in dog and pig as a preclinical test
8. Immunologic considerations in the use of cultured porcine hepatocytes as a hybrid artificial liver. Anti-porcine hepatocyte human serum
9. Molecular barriers to xeno-transplantation
10. Pharmacological studies of FUT-175, nafamostat mesilate. I. Inhibition of protease activity in vitro and in vivo experiments
11. New synthetic inhibitor the alternative complement pathway
12. Modulation of immunologic reactions between cultured porcine hepatocytes and human sera
13. Preparation of isolated rat liver cells
14. Comparison of four methods for mass hepatocyte isolation from pig and human liver
15. Growth of cell-strains and primary cells on micro-carriers in homogeneous culture
16. Immunoprotection of xenocytes in a hollow fiber bioartificial liver
17. Complement activation by xenogeneic red blood cells
18. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primary recipients
19. Beneficial characteristics of protease inhibitor as an anticoagulant for extracorporeal circulation
20. Pharmacokinetic studies of nafamostat mesilate (FUT), a syntetic protease inhibitor, which has been used for treatments of DIC and acute pancreatitis, and as an anticoagulant in extracorporeal circulation
21. Protective effect of nafamostat mesilate on injury of porcine hepatocytes by human plasma
22. Efficacy of nafamostat mesilate for improving the performance of a bioartificial liver using porcine hepatocytes
23. Efficacy of nafamostat mesolate as a regional anticoagulant in experimental direct hemoperfusion and in plasma exchange of humans