Stable transduction with lentiviral vectors and amplification of immature hematopoietic progenitors from cord blood of preterm human fetuses

Human Gene Therapy

Volumn 12, Issue 4, 2001, Pages 377-389

  Luther Wyrsch, A ^a   Costello, E ^b   Thali, M ^b   Buetti, E ^b   Nissen, C ^a   Surbek, D ^a   Holzgreve, W ^a   Gratwohl, A ^a   Tichelli, A ^a   Wodnar Filipowicz, A ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CYTOKINE; ERYTHROPOIETIN; FLT3 LIGAND; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 3; INTERLEUKIN 6; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; STEM CELL FACTOR; VIRUS VECTOR;

ARTICLE; AUTOTRANSPLANTATION; CELL CYCLE G0 PHASE; COLONY FORMING UNIT; CONTROLLED STUDY; DNA MODIFICATION; FETUS; FETUS CELL; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; LENTIVIRINAE; NEWBORN; NORMAL HUMAN; PREMATURITY; PROTEIN EXPRESSION; STEM CELL; TRANSGENE; UMBILICAL CORD BLOOD;

ANTIGENS, CD34; CELL CYCLE; DNA PRIMERS; FEMALE; FETAL BLOOD; GENE AMPLIFICATION; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; GROWTH SUBSTANCES; HEMATOPOIETIC STEM CELLS; HIV-1; HUMANS; INFANT; INFANT, NEWBORN; INFANT, PREMATURE; LEUKEMIA VIRUS, MURINE; LUMINESCENT PROTEINS; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSDUCTION, GENETIC;

LENTIVIRUS; MAMMALIA;

EID: 0035118978     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340150504000     Document Type: Article

References (58)

1. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype
2. Gene silencing as a threat to the success of gene therapy
3. Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults
4. Development of lentiviral vectors for gene therapy for human diseases
5. Circulating hematopoietic progenitor cells in first trimester fetal blood
6. Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors
7. Correction of SCID-X1 disease phenotype following gamma-c gene transfer by a retroviral vector into CD34+ cells in two children
8. Gestational age-dependent changes in circulating hematopoietic stem cells in newborn infants
9. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lymphomyeloid repopulating activity in nonobese diabetic-scid/scid mice
10. Gene transfer into stimulated and un-stimulated T lymphocytes by HIV-1 derived lentiviral vectors
11. Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function
12. Human cord blood CD34+CD38- cell transduction via lentivirus-based gene transfer vectors
13. + cells
14. In utero hematopoietic stem cell transplantation: Ontogenic opportunities and biologic barriers
15. Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow
16. Outcome of cord-blood transplantation from related and unrelated donors
17. Assessment of proliferative and colony-forming capacity after successive in vitro divisions of single human CD34+ cells initially isolated in G0
18. Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production
19. Will ultrasound-screening and ultrasound-guided procedures be replaced by non-invasive techniques for the diagnosis of fetal chromosomal anomalies?
20. The effects of gestation of circulating progenitor cells
21. High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations
22. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency
23. T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates
24. Circulating progenitor cells in human ontogenesis: Response to growth factors and replating potential
25. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors
26. Ex vivo expansion of cord-blood derived stem cells and progenitors
27. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
28. The risks of early cordocentesis (12-21 weeks): Analysis of 500 procedures
29. In vivo footprint and methylation analysis by PCR-aided genomic sequencing: Comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1
30. Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood
31. Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: Evidence for the amplification and self-renewal of repopulating stem cells
32. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is presented by insulators
33. Production of nitric oxide by murine bone marrow cells. Inverse correlation with cellular proliferation
34. Stem cell escalation enables HLA-disparate haematopoietic transplants in leukaemia patients
35. The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites
36. Integration of murine leukemia virus DNA depends on mitosis
37. Outcomes among 562 recipients of placental-blood transplants from unrelated donors
38. In utero gene therapy: The case for
39. Gestational age changes in circulating CD34+ hematopoietic stem/progenitor cells in fetal cord blood
40. Quantitative immunophenotypic characterization, cryopreservation, and enrichment of second and third trimester human fetal cord blood hematopoietic stem/progenitor cells
41. In utero hematopoietic stem cell transfer: Current status and future strategies
42. Functional characterisation of individual human hematopoietic stem cells cultures at limiting dilution of supportive marrow stromal layers
43. Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells
44. Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent
45. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning
46. Embryonic and fetal hemopoiesis: An overview
47. Subpopulations of CD34-positive haemopoietic progenitors in fetal blood
48. In-utero transplantation of stem cells in bare lymphocyte syndrome
49. In utero transplantation of stem cells in humans: Immunological aspects and clinical follow-up of patients
50. Lentiviral vectors: Turning a deadly foe into a therapeutic agent
51. HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells
52. Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor
53. In-utero transplantation of parental CD34 haematopoietic progenitor cells in a patient with X-linked severe combined immunodeficiency (SCIDXI)
54. Stem cell factor stimulates the in vitro growth of bone marrow cells from aplastic anemia patients
55. Umbilical cord blood from preterm human fetuses is rich in committed and primitive hematopoietic progenitors with high proliferative and self-renewal capacity
56. Prospects for in utero human gene therapy
57. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
58. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery