Crystal structure of meso-2,3-butanediol dehydrogenase in a complex with NAD+and inhibitor mercaptoethanol at 1.7 Å resolution for understanding of chiral substrate recognition mechanisms

Journal of Biochemistry

Volumn 129, Issue 2, 2001, Pages 205-208

  Otagiri, Masato ^a   Kurisu, Genji ^a   Ui, Sadaharu ^b   Takusagawa, Yusuke ^b   Ohkuma, Moriya ^c   Kudo, Toshiaki ^c   Kusunoki, Masami ^c  

^a OSAKA UNIVERSITY   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

^c INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

Butanediol dehydrogenase; Chiral recognition; Crystal structure; Klebsiella pneumoniae; Short chain dehydrogenase reductase family; Stereoisomer

Indexed keywords

2,3 BUTANEDIOL DEHYDROGENASE; BACTERIAL ENZYME; GLUTAMINE; GLYCINE; MERCAPTOETHANOL; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHIRALITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; KLEBSIELLA PNEUMONIAE; MOLECULAR RECOGNITION; NONHUMAN; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALCOHOL OXIDOREDUCTASES; CRYSTALLIZATION; KLEBSIELLA PNEUMONIAE; MERCAPTOETHANOL; NAD; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE;

EID: 0035116878     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a002845     Document Type: Article

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