Absence of point mutations within the AML-1 gene in patients with MDS/AML and loss of chromosome 5q or 7

Annals of Hematology

Volumn 80, Issue 2, 2001, Pages 72-73

  Ferrari, T ^a   Weber, B ^a   Pils, S ^a   Harbott, J ^a   Borkhardt, A ^a  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

AML 1 gene; Chromosome 5q or 7q; Deletion; MDS and AML; Tumor suppressor

Indexed keywords

DNA;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BONE MARROW CELL; CHILD; CHROMOSOME 5Q; CHROMOSOME 7Q; CHROMOSOME DELETION; CHROMOSOME LOSS; CHROMOSOME PAINTING; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; EXON; FEMALE; GENE AMPLIFICATION; GENE INACTIVATION; GENE ISOLATION; GENE LIBRARY; GENE SEQUENCE; HUMAN; MALE; MARKER CHROMOSOME; MYELODYSPLASTIC SYNDROME; NUMERICAL CHROMOSOME ABERRATION; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROCESSING; STRUCTURAL CHROMOSOME ABERRATION;

ADOLESCENT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 5; CHROMOSOMES, HUMAN, PAIR 7; DNA, NEOPLASM; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; INFANT; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; POINT MUTATION;

EID: 0035115956     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770000238     Document Type: Article

References (10)

1. The 5q-syndrome
2. A new angle on a pervasive oncogene
3. Heredity and human cancer
4. Catalogue of chromosome aberrations in cancer
5. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
6. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
7. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
8. High incidence of biallelic point mutations in the runt homology domain of the AML1 gene in M0 AML
9. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia
10. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia