The effect of catechol-O-methyltransferase inhibition with entacapone on cardiovascular autonomic responses in L-Dopa-treated patients with Parkinson's disease

Clinical Neuropharmacology

Volumn 24, Issue 1, 2001, Pages 50-57

  Lyytinen, Jukka ^a,c   Sovijärvi, Anssi ^a   Kaakkola, Seppo ^a   Gordin, Ariel ^b   Teräväinen, Heikki ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b ORION CORPORATION   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Autonomic nervous system; Catechol O methyltransferase; Entacapone; Parkinson's disease

Indexed keywords

BROMOCRIPTINE; CATECHOL METHYLTRANSFERASE; DOPA DECARBOXYLASE INHIBITOR; ENTACAPONE; LEVODOPA; PERGOLIDE; PLACEBO;

ADULT; AGED; ARTICLE; CARDIOVASCULAR REFLEX; CARDIOVASCULAR RESPONSE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ENZYME INHIBITION; FEMALE; HAND GRIP; HUMAN; HYPERPNEA; MALE; ORTHOSTATIC HYPOTENSION; PARKINSON DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RR INTERVAL; VALSALVA MANEUVER;

ADULT; AGED; ANTIPARKINSON AGENTS; BLOOD PRESSURE; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HAND STRENGTH; HEART FUNCTION TESTS; HEART RATE; HUMANS; LEVODOPA; MALE; MIDDLE AGED; PARKINSON DISEASE; VALSALVA MANEUVER;

EID: 0035113863     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002826-200101000-00009     Document Type: Article

References (35)

1. Autonomic dysfunction in Parkinson's disease
2. Postural hypotension and low R-R interval variability in parkinsonism, spino-cerebellar degeneration, and Shy-Drager syndrome
3. The deterioration of cardiovascular reflexes in Parkinson's disease
4. Autonomic disturbances and cardiovascular reflexes in idiopathic Parkinson's disease
5. Autonomic deficits in Parkinson's syndrome
6. Autonomic dysfunction in Parkinson's disease, tested with a computerized method using a Finapres device
7. Serum noradrenaline response to standing up in patients with Parkinson's disease
8. Hypotension caused by L-dopa
9. Selegiline diminishes cardiovascular autonomic responses in Parkinson's disease
10. Sympathetic skin response and R-R interval variation in Parkinson's disease
11. General properties and clinical possibilities of new selective inhibitors of catechol-O-methyltransferase
12. Catechol-O-methyltransferase (COMT): Biochemistry, molecular biology, pharmacology and clinical efficacy of the new selective COMT inhibitors
13. Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone
14. Entacapone prolongs levodopa response in a one-month double-blind study in parkinsonian patients with levodopa related fluctuations
15. Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients
16. Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations
17. Noradrenaline: Fate and control of its biosynthesis
18. The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise
19. COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise
20. Simultaneous MAO-B and COMT inhibition in L-Dopa treated patients with Parkinson's disease
21. Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease
22. Testing autonomic function
23. Consensus statement of the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy
24. Dysphagia in Parkinson's disease
25. Lewy bodies in the visceral autonomic nervous system in Parkinson's disease
26. Cardiac sympathetic denervation from the early stage of Parkinson's disease: Clinical and experimental studies with radiolabeled MIBG
27. The influence of the type, duration, severity and levodopa treatment of Parkinson's disease on cardiovascular autonomic responses
28. Neuropathology and cardiovascular regulation
29. Autonomic effects of selegiline: Possible cardiovascular toxicity in Parkinson's disease
30. Effects of COMT inhibitors on striatal dopamine metabolism: A microdialysis study
31. Catecholamine metabolism: Basic aspects and clinical significance
32. Dopamine sulfoconjugation in the rat brain: Regulation by monoamine oxidase
33. Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on hemodynamics and catecholamine metabolism in healthy volunteers