A novel activation of Ca2+-activated Cl- channel in Xenopus oocytes by ginseng saponins: Evidence for the involvement of phospholipase C and intracellular Ca2+ mobilization

British Journal of Pharmacology

Volumn 132, Issue 3, 2001, Pages 641-648

  Choi, Seok ^a   Rho, Seong Hwan ^b   Jung, Se Yeon ^a   Kim, Seok Chang ^c   Park, Chul Seung ^b   Nah, Seung Yeol ^a  

^a Chonnam National University   (South Korea)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

^c Korea Ginseng Corporation   (South Korea)

Author keywords

Ginseng; Ginsenosides; PLC; Xenopus oocytes

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE GUANOSINE TRIPHOSPHATE; CALCIUM ION; CHLORIDE CHANNEL; CHLORIDE ION; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GINSENG SAPONIN; GINSENOSIDE; HEPARIN; PERTUSSIS TOXIN; PHOSPHOLIPASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; DRUG ACTIVATION; FEMALE; MEMBRANE CURRENT; MEMBRANE POTENTIAL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VOLTAGE CLAMP; XENOPUS;

EID: 0035112689     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703856     Document Type: Article

References (31)

1. A transient calcium-dependent chloride current in the immature Xenopus oocyte
2. Inositol triphosphates and cell signalling
3. Inactivation of calcium-activated chloride conductance in Xenopus oocytes: Roles of calcium and protein kinase C
4. 2+
5. Cloning of an epithelial chloride channel from bovine trachea
6. Acetylcholine promotes progesterone-induced maturation of Xenopus oocytes
7. - currents in X. laevis oocytes
8. Hyaluronan activates calcium-dependent chloride currents in Xenopus oocytes
9. Molecular and functional characterization of a calcium-sensitive chloride channel from mouse lung
10. - channel proteins
11. Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes
12. Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx
13. Effects of ginsenosides on pp60c-sre kinase, intracellular calcium and cell proliferation in NIH 3T3 cells
14. Functional expression of a truncated Ca2+-activated Cl- channel and activation by phorbol ester
15. Effects of ginsenosides on Ca channels and membrane capacitance in rat adrenal chromaffin cells
16. Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells
17. Molecular mechanisms of intracellular calcium excitability in Xenopus laevis oocytes
18. Chloride current induced by injection of calcium into Xenopus oocytes
19. Ginseng: Recent advances and trends
20. Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as μ-type opioids
21. 2+ channels through a pertussis toxin-sensitive G protein
22. - current in Xenopus oocytes
23. Isolation and functional reconstitution of a 38-kDa chloride channel protein from bovine tracheal membranes
24. Effect of ginsenosides from red ginseng on the enzymes of cellular signal transduction system
25. The effect of ginseng components on the signal transduction in the activation of murine macrophages
26. + influx and catecholamine secretion in bovine adrenal chromaffin cells
27. The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells
28. Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells
29. Effect of phorbol ester and calcium ionophore on chloride secretion in canine tracheal epithelium
30. - channels in Xenopus oocytes
31. 2+ liberation from intracellular stores