Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2): Analysis of association with schizophrenia

Molecular Psychiatry

Volumn 6, Issue 2, 2001, Pages 186-192

  Joo, A ^a   Shibata, H ^a   Ninomiya, H ^b   Kawasaki, H ^b   Tashiro, N ^b   Fukumaki, Y ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Metabotropic glutamate receptor type 2 gene; Polymorphisms; RH mapping; Schizophrenia; SSCP

Indexed keywords

COMPLEMENTARY DNA; EGLUMETAD; GLUTAMATE RECEPTOR; MESSENGER RNA; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR AGONIST; PHENCYCLIDINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHROMOSOMAL LOCALIZATION; CONTROLLED STUDY; EXON; GEL ELECTROPHORESIS; GENE FREQUENCY; GENE ISOLATION; GENE LIBRARY; GENE MAPPING; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; RECEPTOR GENE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION;

BRAIN CHEMISTRY; CASE-CONTROL STUDIES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 3; DNA PRIMERS; DNA, COMPLEMENTARY; EXONS; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECEPTORS, METABOTROPIC GLUTAMATE; RNA SPLICE SITES; SCHIZOPHRENIA;

EID: 0035112644     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000841     Document Type: Article

References (28)

1. Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity
2. Molecular diversity of glutamate receptors and their physiological functions
3. Metabotropic glutamate receptor activation and blockade: Their role in long-term potentiation, learning and neurotoxicity
4. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination
5. Group-I metabotropic glutamate receptors: Hypotheses to explain their dual role in neurotoxicity and neuroprotection
6. Constrains on concepts of pathogenesis
7. Glutamate receptor expression in schizophrenic brain
8. Glutamate receptor dysfunction and schizophrenia
9. Recent advances in the phencyclidine model of schizophrenia
10. Axon-target interactions maintain synaptic gene expression in retinae transplanted to intracranial regions of the rat
11. Experimental down-regulation of the NMDA channel associated with synapse pruning
12. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
13. The metabotropic glutamate receptors: Structure and functions
14. Corticolimbic dopamin neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine
15. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats
16. Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice
17. Screening of recombinant DNA libraries
18. Single-strand conformation polymorphism analysis
19. Testing linkage disequilibrium between a disease gene and marker loci
20. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence
21. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2
22. Linkage and associated studies of schizophrenia
23. Structural organization of the mouse metabotropic glutamate receptor subtype 3 gene and its regulation by growth factors in cultured cortical astrocytes
24. Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus
25. Probing the ligand-binding domain of the mGluR4 subtype of metabotropic glutamate receptor
26. A family of metabotropic glutamate receptors
27. Low nucleotide diversity in man
28. The essense of SNPs