HNS-32, a novel azulene-1-carboxamidine derivative, inhibits nifedipine-sensitive and -insensitive contraction of the isolated rabbit aorta

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 363, Issue 3, 2001, Pages 344-352

  Tanaka, Yoshio ^a   Mitani, Akiko ^a   Igarashi, Tomomi ^a   Someya, Shinnosuke ^a   Otsuka, Kazuoki ^a   Imai, Toshiyasu ^a   Yamaki, Fumiko ^a   Tanaka, Hikaru ^a   Saitoh, Masaki ^b   Nakazawa, Tomoo ^b   Noguchi, Kazuo ^c   Hashimoto, Keitaro ^b   Shigenobu, Koki ^a  

^a TOHO UNIVERSITY   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

^c TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Azulene 1 carboxamidine derivatives; HNS 32; L type Ca2+ channel; N1, N1 dimethyl N2 (2 pyridylmethyl) 5 isopropyl 3, 8 dimethylazulene 1 carboxamidine; Nifedipine; Nitroglycerin; Phorbol 12, 13 dibutyrate; Rabbit aorta; Vascular smooth muscle

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINOPYRIDINE; 5 ISOPROPYL 3,8,N1,N1 TETRAMETHYL N2 (2 PYRIDYLMETHYL) 1 AZULENECARBOXAMIDINE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ACETYLCHOLINE; APAMIN; AZULENE DERIVATIVE; BARIUM ION; CALCIUM CHANNEL L TYPE; FORSKOLIN; GLIBENCLAMIDE; GLYCERYL TRINITRATE; GUANETHIDINE; N1,N1 DIMETHYL N2 (2 PYRIDYLMETHYL) 5 ISOPROPYL 3,8 DIMETHYLAZULENE 1 CARBOXAMIDE; NIFEDIPINE; NORADRENALIN; PHORBOL DIBUTYRATE; POTASSIUM CHLORIDE; TETRODOTOXIN; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA MEDIA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; INHIBITION KINETICS; MALE; NONHUMAN; RABBIT; SMOOTH MUSCLE CONTRACTILITY; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; AORTA, THORACIC; CALCIUM CHANNEL BLOCKERS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FORSKOLIN; MALE; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NIFEDIPINE; NITROGLYCERIN; NOREPINEPHRINE; PHORBOL 12,13-DIBUTYRATE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHLORIDE; PROTEIN KINASE C; PYRIDINES; RABBITS; TETRAETHYLAMMONIUM; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0035111619     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000368     Document Type: Article

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