Evidence for involvement of dysfunctional teeth in the senile process in the hippocampus of SAMP8 mice

Experimental Gerontology

Volumn 36, Issue 2, 2001, Pages 283-295

  Watanabe, K ^a   Tonosaki, K ^b   Kawase, T ^c   Karasawa, N ^d   Nagatsu, I ^d   Fujita, M ^a   Onozuka, M ^a,e  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c KANAGAWA DENTAL COLLEGE   (Japan)

^d FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e Tel: +81 58 267 2221 ^*  (Japan)

Author keywords

Hippocampal neuronal degeneration; Mastication; SAMP8 mice; Senile dementia; Spatial memory

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

ACCELERATED SENESCENCE PRONE MOUSE; AGE; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEARNING; MALE; MASTICATION; MAZE TEST; MOLAR TOOTH; MORPHOMETRICS; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; SENESCENCE ACCELERATED MOUSE; SENILE DEMENTIA; SPATIAL MEMORY; TOOTH EXTRACTION;

AGING, PREMATURE; ANIMALS; CELL COUNT; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MAZE LEARNING; MICE; MICE, MUTANT STRAINS; MOLAR; NERVE DEGENERATION;

EID: 0035111246     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00216-3     Document Type: Article

References (30)

1. Stereological estimation of the total number of neurons in the murine hippocampus using the optical disector
2. Image analysis of GFAP-positive astrocytes from adolescence to senescence
3. The astrocytic response to afferent activity blockade in chick nucleus magnocellularis is independent on synaptic activation, age and neuronal survival
4. Rapid and reversible astrocytic reaction to afferent activity blockade in the chick cochlear nucleus
5. Soft-diet feeding during development enhances later learning ability in female rats
6. RNA and protein metabolism in the aging brain
7. Age-related impairment in learning but not memory in SAMP8 female mice
8. Management and design of the maintenance of SAM mouse strains: an animal model for accelerated senescence and age-associated disorders
9. Interventions of senescence in SAM mice
10. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats
11. The effect of the loss of molar teeth on spatial memory and acetylcholine release from the parietal cortex in aged rats
12. A case-control study of Alzheimer's disease in Japan: significance of life-styles
13. Degenerative changes of primary neurons following tooth extraction
14. Pattern of astroglial hypertrophy and neuronal degeneration in the hippocampus of aged, memory-deficient rats
15. Basal ACTH, corticosterone and corticosterone-binding globulin levels over the diurnal cycle, and age-related changes in hippocampal type I and type II corticosteroid receptor binding capacity in young and aged, handled and nonhandled rats
16. Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)
17. Life and death of neurons in the aging brain
18. Behavioral characteristics of the SAM-P/8 stain in the Sidman active avoidance task
19. The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain
20. Reduced mastication stimulates impairment of spatial memory and degeneration of hippocampal neurons in aged SAMP8 mice
21. Impairment of spatial memory and changes in astroglial responsiveness following loss of molar teeth in aged SAMP8 mice
22. Rapid growth of astrocytic processes in the N. magnocellularis following cochlea removal
23. Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease
24. Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo
25. Decrease in the learning and memory ability induced by reduction of masticatory movement in the senescence-accelerated mouse
26. Unbiased stereological estimation of the number of neurons in the human hippocampus
27. New stereological methods for counting neurons
28. Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbance in recent memory