Cytotoxic T lymphocytes from HLA-A2.1 transgenic mice define a potential human epitope from simian virus 40 large T antigen

Cancer Research

Volumn 61, Issue 3, 2001, Pages 873-879

  Schell, Todd D ^a   Lippolis, John D ^b   Tevethia, Satvir S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA A2 ANTIGEN; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EPITOPE MAPPING; HLA SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIMIAN VIRUS 40;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; ANTIGENS, VIRAL, TUMOR; CELL LINE; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HLA-A2 ANTIGEN; HUMANS; LYMPHOCYTE ACTIVATION; MICE; PEPTIDE FRAGMENTS; SIMIAN VIRUS 40; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035110715     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Cell and molecular biology of simian virus 40: Implications for human infections and disease
2. Transgenic mice and oncogenesis
3. DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood
4. Simian vires 40-like DNA sequences in human pleural mesothelioma
5. The human polyomaviruses, BKV and JCV: Molecular pathogenesis of acute disease and potential role in cancer
6. Early regions of JC vires and Bk vires induce distinct and tissue-specific tumors in transgenic mice
7. BK virus T antigens induce kidney carcinomas and thymoproliferative disorders in transgenic mice
8. SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals
9. Human exposure to SV40: Review and comment
10. Recognition of simian vires 40 T antigen by cytotoxic T lymphocytes
11. Clustering of antigenic sites recognized by cytotoxic T lymphocyte clones in the amino terminal half of SV40 T antigen
12. b-restricted cytotoxic Tlymphocyte clones and a synthetic peptide
13. Cytotoxic T lymphocyte recognition sequences as markers for distinguishing among tumour antigens encoded by SV40, BKV and JCV
14. Cytotoxic T cell responses in HLA-A2.1 transgenic mice. Recognition of HLA alloantigens and utilization of HLA-A2.1 as a restriction element
15. b-restricted determinant in simian vires 40 tumor antigen
16. +T-lymphocyte responses to multiple epitopes from simian virus 40 (SV40) large T antigen in C57BL/6 mice immunized with SV40, SV40 T-antigen-transformed cells, or vaccinia virus recombinants expressing full-length T antigen or epitope minigenes
17. An endoplasmic reticulum-targeting signal sequence enhances the immunogenicity of an immunorecessive simian virus 40 large T antigen cytotoxic T-lymphocyte epitope
18. Biology of simian virus 40 (SV40) transplantation rejection antigen (TrAg). In vitro demonstration of SV40 TrAg in SV40 infected non-permissive mouse cells by the lymphocyte-mediated cytotoxicity assay
19. Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated large T antigens
20. Tumor antigen and human chorionic gonadotropin in CaSki cells: A new epidermoid cervical cancer cell line
21. Localization of common cytotoxic T lymphocyte recognition epitopes on simian papovavirus SV40 and human papovavirus JC virus T antigens
22. Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutations
23. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
24. Expression of herpes simplex virus glycoprotein B by a recombinant vaccinia virus and protection of mice against lethal herpes simplex virus 1 infection
25. Detection of shared MHC-restricted human melanoma antigens after vaccinia virus-mediated transduction of genes coding for HLA
26. TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but not carboxyl-terminus of the peptide
27. Defective and nondefective AD2-SV40 hybrids
28. Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides
29. Hepatitis B synthetic immunogen comprised of nucleocapsid T-cell sites and an envelope B-cell epitope
30. Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice
31. Human leukocyte antigen-A2.1 restricted candidate cytotoxic T lymphocyte epitopes of human papil lomavirus type 16 E6 and E7 proteins identified by using the processing-defective human cell line T2
32. Phenotypic analysis of antigen-specific T lymphocytes
33. Efficient lysis of human immunodeficiency virus type l-infected cells by cytotoxic T lymphocytes
34. Definition of a human T cell epitope from influenza A non-structural protein I using HLA-A2.1 transgenic mice
35. MHC ligands and peptide motifs: First listing
36. Defective presentation of endogenous antigen by a cell line expressing class I molecules
37. The three-dimensional structure of peptide-MHC complexes
38. Simian virus-40 large-T antigen binds p53 in human mesotheliomas
39. The retinoblastoma gene family pRb/pl05, p107, pRb2/pl30 and simian virus-40 large T-antigen in human mesotheliomas
40. Differences and similarities in the A2. I-restricted cytotoxic T cell repertoire in humans and human leukocyte antigen-transgenic mice
41. Sequential loss of cytotoxic T lymphocyte responses to simian virus 40 large T antigen epitopes in T antigen transgenic mice developing osteosarcomas