Aminoguanidine and ramipril prevent diabetes-induced increases in protein kinase C activity in glomeruli, retina and mesenteric artery

Clinical Science

Volumn 100, Issue 3, 2001, Pages 249-257

  Osicka, T M ^a   Yu, Y ^a   Lee, V ^a   Panagiotopoulos, S ^a   Kemp, B E ^a   Jerums, G ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Advanced glycation end products; Albuminuria; Angiotensin II; Glomeruli; Mesenteric artery; Retina

Indexed keywords

AMINOGUANIDINE; INSULIN; PROTEIN KINASE C; RAMIPRIL; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; GLOMERULUS; GLYCATION; INSULIN TREATMENT; MALE; MESENTERIC ARTERY; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; RAT; RETINA;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; CAPILLARY PERMEABILITY; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; GLYCOSYLATION END PRODUCTS, ADVANCED; GUANIDINES; HEMOGLOBIN A, GLYCOSYLATED; HYPOGLYCEMIC AGENTS; INSULIN; KIDNEY GLOMERULUS; MALE; MESENTERIC ARTERIES; PROTEIN KINASE C; RAMIPRIL; RATS; RATS, SPRAGUE-DAWLEY; RETINA;

EID: 0035108843     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20000194     Document Type: Article

References (38)

1. Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
2. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation
3. Normalization of diacylglycerol protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels
4. Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: Possible mediation by glucose
5. Amelioration of vascular dysfunction in diabetic rats by an oral PKC β inhibitor
6. Diacylgycerol accumulation and microvascular abnormalities induced by elevated glucose levels
7. Characterisation of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia
8. Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells
9. Factors controlling growth and matrix production in vascular smooth muscle and glomerular mesangial cells
10. Experimental diabetes is associated with functional activation of protein kinase C epsilon and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade
11. Molecular identity and cellular distribution of advanced glycation endproduct receptors: Relationship of p60 to OST-48 and p90 to 80K-H membrane proteins
12. Role of angiotensin II and bradykinin in experimental diabetic nephropathy. Functional and structural studies
13. Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozotocin-induced diabetic rat
14. Vascular hypertrophy in experimental diabetes: Role of advanced glycation endproducts
15. Angiotensin converting enzyme inhibition ameliorates retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes
16. Validation in awake rats of a tail-cuff method for measuring systolic blood pressure
17. Glycohemoglobin measured by automated affinity HPLC correlates with both short-term and long-term antecedent glycemia
18. Glomerular filtration rate in earn experimental diabetes
19. The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat
20. Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters, in PC12 pheochromocytoma cells
21. Studies on the renal glomerular basement membrane. Preparation and chemical composition
22. Effects of very mild overt diabetes on vascular haemodynamics and barrier function in rats
23. 131I-labelled human growth hormone of high specific radioactivity
24. Prevention of albuminuria by aminoguanidine or ramipril in STZ-diabetic rats is associated with the normalisation of glomerular protein kinase C
25. Prevention of glomeruli dysfunction in diabetic rats by treatment with d-α-tocopherol
26. Effects of aminoguanidine (AG) on hyperglycemia-induced retinal metabolic abnormalities
27. Abnormalities of retinal metabolism in diabetes or experimental galactosemia
28. Protein kinase C activation and the development of diabetic complications
29. Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy
30. Angiotensin converting enzyme inhibition and calcium antagonism attenuate streptozotocin-diabetes associated mesenteric vascular hypertrophy independently of their hypotensive action
31. Alterations in endothelium-dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats
32. Role of endothelium-derived nitric oxide in the pathogenesis of the renal hemodynamic changes in experimental diabetes
33. Acute renal hemodynamic effects of ACE inhibition in diabetic hyperfiltration: Role of kinins
34. Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor
35. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice - A potential mechanism for the accelerated vasculopathy of diabetes
36. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction
37. Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats
38. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways