Cytotoxicity of novel trifluoromethylquinoline derivatives on human leukemia cells

European Journal of Pharmaceutical Sciences

Volumn 12, Issue 4, 2001, Pages 369-376

  Kgokong, Joseph L ^a   Wachira, James M ^a  

^a UNIVERSITY OF LIMPOPO   (South Africa)

Author keywords

Cytotoxicity; DNA binding; Promyelocytic leukemic cells; Trifluoromethylquinoline derivatives

Indexed keywords

2,8 BIS(TRIFLUOROMETHYL)QUINOLINE 4 (4N ETHYL 5 NITROIMIDAZOLO)METHYLENE KETONE; 8 TRIFLUOROMETHYLQUINOLINE 4 (4N ETHYL 5 NITROIMIDAZOLO)METHYLENE KETONE; QUINOLINE DERIVATIVE; TRIFLUOROMETHYLQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DNA BINDING; FLUORESCENCE; HUMAN; HUMAN CELL; LEUKEMIA CELL; MICROSCOPY; PRIORITY JOURNAL;

APOPTOSIS; CELL SURVIVAL; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHIDIUM; HL-60 CELLS; HUMANS; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035107954     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00137-8     Document Type: Article

References (25)

1. The Iron environment in heme and heme-antimalarial complexes of pharmacological interest
2. Nonintercalative DNA-binding antitumour compounds
3. Topoisomerases as novel targets for cancer chemotherapy
4. Potential antitumor agents. 28. Deoxyribonucleic acid polyintercalating agents
5. Structure and antimalarial activity of aminoalcohols and 2-(p-chlorophenyl)-2-(4-piperidyl)tetrahydrofuran
6. Evidence for antimalarial drug binds to membrane phospholipids
7. Synthesis and antitumor activities of quinolone antiplastic agents
8. Biological characterization of a novel antitumor Quinolone
9. Towards the rational design of antimalarial drugs
10. Detection of apoptosis in KG-1a Leukemic cells treated with investigational drugs
11. Studies on modes of action of chloroquine, quinacrine and quinine and on chloroquine resistance
12. Reading the minor grooves
13. Synthesis of two novel Thioacridinic derivatives and comparison of their in vitro biological activities
14. Antimalarials. 7-Bis(trifluoromethyl)-α-(2-piperidyl-4-quinolinemethanol
15. Antimalarials. 6. Some of the new α-Alkylamino-methyl-4-quinolinemethanols
16. Hemoglobin catabolism and iron utilisation by malaria parasites
17. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells
18. α-(4-amino-4-deoxypteroyl)-L-ornithine derivatives. Synthesis and in vitro antitumour activity
19. Spectroscopic studies on the interaction of three partially hydrogenated acridine dyes with calf thymus DNA and their structural comparison
20. The effect of structural changes in a polyamine backbone on its DNA-binding properties
21. Quinolones: structure-activity relationships and future predictions
22. The binding of primaquine, pentaquine, pamaquine, and plasmocid to deoxyribonucleic acid
23. Antitumor quinolones with mammalian topoisomerase II mediated DNA cleavage activity
24. DNA topoisomerase inhibitors: cytotoxic flavones from Lethedon tannaensis