On sample size and inference for two-stage adaptive designs

Biometrics

Volumn 57, Issue 1, 2001, Pages 172-177

  Liu, Qing ^a   Chi, George Y H ^b  

^a CEPHALON INC   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Adaptive design; Adjusted confidence intervals; Adjusted p value; Conditional error; Exact inference; Fisher's combination test; Point estimate; Sample size adjustment; Type I error rate

Indexed keywords

ADAPTIVE DESIGNS; ADJUSTED CONFIDENCE INTERVAL; ADJUSTED P-VALUES; CONDITIONAL ERROR; CONFIDENCE INTERVAL; EXACT INFERENCE; FISHER COMBINATION TEST; POINT ESTIMATE; SAMPLE SIZE ADJUSTMENT; SAMPLE SIZES; TYPE I ERROR RATE;

ERROR ANALYSIS;

ANALYTICAL ERROR; ARTICLE; BIOMETRY; DATA ANALYSIS; METHODOLOGY; SAMPLE; STATISTICAL MODEL;

MARTES PENNANTI;

EID: 0035106146     PISSN: 0006341X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0006-341X.2001.00172.x     Document Type: Article

References (7)

1. Evaluations of experiments with adaptive interim analyses
2. Self-designing clinical trials
3. Sequential monitoring of clinical trials: The role of information and Brownian motion
4. Designed extension of studies based on conditional power
5. Statistical inference for self-designing clinical trials with a one-sided hypothesis
6. A comparison of two methods for adaptive interim analyses in clinical trials