Rapid desensitization of 5-HT1A receptors in Fawn-Hooded rats after chronic fluoxetine treatment

European Neuropsychopharmacology

Volumn 11, Issue 1, 2001, Pages 15-24

  Kantor, S ^a   Graf, M ^a   Anheuer, Z E ^a   Bagdy, G ^a  

^a NATIONAL INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Hungary)

Author keywords

5 HT transporter; 5 HT1A receptor; Anxiety; Depression; Fawn Hooded rat; Hypothermia; Receptor desensitization; SSRI antidepressant

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; FLUOXETINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RECEPTOR SUBTYPE; SEROTONIN 1A RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; DEPRESSION; HYPOTHERMIA; LOWER LIP; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RECEPTOR DOWN REGULATION; SEROTONIN BLOOD LEVEL; SOCIAL INTERACTION; THROMBOCYTE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ANXIETY DISORDERS; BODY TEMPERATURE; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; FLUOXETINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN UPTAKE INHIBITORS;

EID: 0035105045     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(00)00126-7     Document Type: Article

References (79)

1. Increased mRNA for corticotropin releasing hormone in the amygdala of Fawn-Hooded rats: a potential animal model of anxiety
2. 5-HT and antidepressants: new views from microdialysis studies
3. A comparison of feeding and locomotion responses to serotonin agonist in three rat strains
4. Functional and biochemical evidence for altered serotonergic function in the Fawn-Hooded rat strain
5. Food intake, neuroendocrine and temperature effects of 8-OH-DPAT in the rat
6. Comparison of relative potencies of i.v. and i.c.v. administered 8-OH-DPAT gives evidence of different sites of action for hypothermia, lower lip retraction and tail flicks
7. Role of dorsal and median raphe nuclei in lower lip retraction in rats
8. Antagonism of 8-OH-DPAT-induced behavior in rats
9. Selective activation of 5-HT1A receptors induces lower lip retraction in the rat
10. Current advances and trends in the treatment of depression
11. Effect of repeated electroconvulsive shocks on serotonergic neurons
12. Modulation of 5-HT release in the guinea-pig brain following long-term administration of antidepressant drugs
13. Differential responsiveness of the rat dorsal and median raphe 5-HT systems to 5-HT1 receptor agonist and p-chloramphetamine
14. Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat
15. Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in 5-HT1A and 5-HT1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats
16. Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex
17. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat
18. 5-HT1A receptor sensitivity in major depression: A neuroendocrine study with buspirone
19. Thermoregulatory responses following injection of 5-hydroxytryptamine into the septohippocampal complex in rats
20. Effect of serotonin uptake inhibitors in anxiety disorders, a double blind comparison of clomipramine and fluvoxamine
21. Alcohol selection by strains of rats selectively bred for behavior
22. The serotonin reuptake inhibitor paroxetine is superior to the noradrenaline reuptake inhibitor maprotiline in the treatment of premenstrual syndrome
23. Can social interaction be used to measure anxiety?
24. Differentiation of 8-OH-DPAT and ipsapirone in rat models of 5-HT1A receptor function
25. The pharmacology of the hypothermic response in mice to 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT): a model of presynaptic 5-HT1 function
26. Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock
27. Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat
28. The pharmacology of the behavioral and hypothermic responses of the rats to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)
29. 5-HT1A receptor blockers as potential drug candidates for the treatment of anxiety disorders
30. Altered responses to serotonergic agents in Fawn-Hooded rats
31. Human platelet serotonin content: methodological aspects and physiological variations
32. Chronic electroconvulsive shock and 5-HT autoreceptor activity in rat brain: an in vivo microdialysis study
33. Pharmacological characterization of a modified social interaction model of anxiety in the rat
34. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission
35. Inhibition of median and dorsal raphe neurons following administration of the selective serotonin reuptake inhibitor paroxetine
36. Evidence for a repetitive (burst) firing pattern in a sub-population of 5-hydroxytryptamine neurons in the dorsal and median raphe nuclei of the rat
37. A quantitative autoradiographic study of serotonin1A receptor regulation: effect of 5,7-dihydroxytryptamine and antidepressant treatments
38. Behavioral and biochemical consequences following activation of 5-HT1-like and GABA receptors in the dorsal raphe nucleus of the rat
39. Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the rat
40. Hypothermia in the rat induced by the potent serotonergic agent 8-OH-DPAT
41. Lack of 5-HT1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis
42. Regional analysis of 5-HT1A and 5-HT2 receptors in the Fawn-Hooded rat
43. Hypothermia induced by putative 5-HT1A agonist LY 165163 and 8-OH-DPAT is not prevented by 5-HT depletion
44. Chronic treatment with citalopram facilitates the effect of challenge dose on cortical serotonin output: role of pre-synaptic 5-HT1A receptors
45. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram
46. Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists
47. Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-HT measured in vivo
48. 5-HT1A receptor function in normal subjects on clinical doses of fluoxetine: blunted temperature and hormone responses to ipsapirone challenge
49. Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression
50. Long-term fluoxetine treatment decreases 5-HT1A receptor responsivity in obsessive compulsive disorder
51. Attenuation of hormone responses to the 5-HT1A agonist ipsapirone by long-term treatment with fluoxetine, but not desipramine, in male rats
52. Long-term fluoxetine, but not desipramine, inhibits the ACTH and oxytocin responses to the 5-HT1A agonist, 8-OH-DPAT, in male rats
53. A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of GI and GO proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors
54. Anxiolytic-like effect of paroxetine in a rat social interaction test
55. Effects of pindolol on the L-5-HTP induced increase in plasma prolactin and cortisol concentrations in man
56. Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists
57. Lower lip retraction is selectively mediated by activation of the 5-HT1A receptor
58. The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments
59. 5-HT1A mediated lower lip retraction: effects of 5-HT1A agonists and antagonists
60. Regulation of 5-HT1A receptor function in rat hippocampus by short- and long-term administration of 5-HT1A agonists and antidepressants
61. Effect of repeated treatment with electroconvulsive shock (ECS) on serotonin receptor density and turnover in the rat cerebral cortex
62. Clinical pharmacology of anxiolytics and antidepressants: a psychopharmacological perspective
63. Evidence for postsynaptic mediation of the hypothermic effect of 5-HT1A receptor activation
64. Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism
65. Serotonin uptake blockers inhibit the firing of presumed serotonergic dorsal raphe neurons in vitro
66. Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine
67. Emotional reactivity and alcohol-preference among genetic crosses of the Moudsley and Roman rats
68. Effect of various antidepressant drugs on the spontaneous firing rate of locus coeruleus and dorsal raphe neurons of the rat
69. Electrophysiological evidence for a functional differentiation between subtypes of 5-HT1 receptor
70. Consequences of 5-HT re-uptake blockade on postsynaptic 5-HT1A receptor activation: an electrophysiological and neurochemical study in guinea pig dorsal raphe and hippocampus
71. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5-HT transporter
72. Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine and ipsapirone treatment
73. Effects of acute and chronic fluoxetine treatment on CRH induced anxiety
74. Platelet storage pool disease in hybrid rats
75. Fawn-hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists
76. Altered responses to psychoactive drugs and spontaneous behavior differences in mice lacking the serotonin transporter
77. Serotonin and animal behavior
78. Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication
79. The effect of chronic administration of antidepressants and electroconvulsive shock on the 5-HT1A receptor mediated hypothermic response induced by 8-OH-DPAT in the rat