Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping

Haematologica

Volumn 86, Issue 2, 2001, Pages 154-161

  Wuchter, C ^a   Ratei, R ^a   Spahn, G ^a   Schoch, C ^a   Harboit, J ^a   Schnittger, S ^a   Haferlach, T ^a   Creutzig, U ^a   Sperling, C ^a   Karawajew, L ^a   Ludwig, W D ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Acute leukemia; CD133 (AC133); CD90; Flow cytometry; Immunophenotyping

Indexed keywords

CD133 ANTIGEN; CD34 ANTIGEN; LEUKEMIA ANTIGEN; MONOCLONAL ANTIBODY; THY 1 ANTIGEN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CYTOGENETICS; FLOW CYTOMETRY; GENE TRANSLOCATION; HUMAN; IMMUNOPHENOTYPING; IMMUNOREACTIVITY; INFANT; MAJOR CLINICAL STUDY; PRESCHOOL CHILD; SCHOOL CHILD;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD34; ANTIGENS, THY-1; CELL LINEAGE; CHILD; CHILD, PRESCHOOL; GLYCOPROTEINS; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOPHENOTYPING; INFANT; LEUKEMIA; MIDDLE AGED; PEPTIDES;

EID: 0035104257     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia
2. Stem cell origins of leukaemia and curability
3. Biology of acute leukaemia
4. CD34: Structure, biology, and clinical utility
5. Proposals for the immunological classification of acute leukemias
6. A novel five-transmembrane hematopoietic stem cell antigen: Isolation, characterization, and molecular cloning
7. AC133, a novel marker for human hematopoietic stem and progenitor cells
8. Isolation and characterization of human CD34(-) Lin(-) and CD34(+)Lin(-) hematopoietic stem cells using cell surface markers AC133 and CD7
9. AC133 hematopoietic stem cell antigen: Human homologue of mouse kidney prominin or distinct member of a novel protein family?
10. A response to AC133 hematopoietic stem cell antigen: Human homologue of mouse kidney prominin or distinct member of a novel protein family?
11. The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions
12. Expression of VEG-FR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors
13. Expression of the AC133 antigen in leukemic and normal progenitors
14. Expression of AC133, a novel hematopoietic precursor antigen, on acute myeloid leukemia cells
15. AC133 antigen expression is not restricted to acute myeloid leukemia blasts but is also found on acute lymphoid leukemia blasts and on a subset of CD34+ B-cell precursors
16. Expression of AC133 and CD117 on candidate normal stem cell populations in childhood B-cell precursor acute lymphoblastic leukaemia
17. Expression of a AC133, a novel stem cell marker, on human leukemic blasts lacking CD34-antigen and on a human CD34+ leukemic line:MUTZ-2
18. Discordant expression of AC133 and AC141 in patients with myelodysplastic syndrome (MDS) and acute myelogeneous leukemia (AML)
19. Expression of Thy-1 on human hematopoietic progenitor cells
20. Proposals for the classification of the acute leukaemias
21. Clinical significance of surface antigen expression in children with acute myeloid leukemia: Results of study AML-BFM-87
22. Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: Results of the German multicenter trials GMALL 03/87 and 04/89
23. Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors
24. Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse
25. Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis
26. A single tube nested RT-PCR for detecting the common myeloid specific chromosomal translocations
27. Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92
28. The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias
29. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo
30. Thy-1 expression on blast cells from adult patients with acute myeloid leukemia
31. Expression of Thy-1 antigen (CDw90) on adult acute leukemia blast cells
32. Characterization of Thy-1 (CDw90) expression in CD34+ acute leukemia
33. Immunophenotypic differences between putative hematopoietic stem cells and childhood B-cell precursor acute lymphoblastic leukemia cells
34. Oncogenic transcription factors in the human acute leukemias
35. 11q23 rearrangements in acute leukemia
36. ALL1 gene alterations in acute leukemia: Biological and clinical aspects
37. Frequent expression of human Thy-1 antigen on pre-B cell acute lymphoblastic leukemia with t(9;22)
38. Definition of acute biphenotypic leukemia
39. Adult biphenotypic acute leukaemia: An entity with poor prognosis which is related to unfavourable cytogenetics and P-glycoprotein over-expression
40. Cytogenetic findings in acute biphenotypic leukaemia
41. Outcome of biphenotypic acute leukemia
42. Chronic myeloid leukemia from basics to bedside
43. Philadelphia chromosome-positive cells are equally distributed in AC133+ and AC133- fractions of CD34+ peripheral blood progenitor cells from patients with CML
44. Impact of immunophenotyping on management of acute leukemias