TIMP-1 production by human scleral fibroblast decreases in response to cyclic mechanical stretching

Ophthalmic Research

Volumn 33, Issue 2, 2001, Pages 98-101

  Yamaoka, Akihiro ^a   Matsuo, Toshihiko ^a   Shiraga, Fumio ^a   Ohtsuki, Hiroshi ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Human scleral fibroblast; Mechanical stretching; MMP 1; MMP 2; TIMP 1

Indexed keywords

GELATINASE A; INTERSTITIAL COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

AGED; ARTICLE; CELL GROWTH; CONTROLLED STUDY; ENZYME IMMUNOASSAY; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; FIBROBLAST CULTURE; HOMEOSTASIS; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RETINA SURGERY; SCLERA; STRETCHING;

AGED; AGED, 80 AND OVER; CELLS, CULTURED; FEMALE; FIBROBLASTS; HUMANS; MALE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; SCLERA; STRESS, MECHANICAL; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 0035104103     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055651     Document Type: Article

References (10)

1. Increased expression of matrix metalloproteinases in vivo in scleritis tissue and in vitro in cultured human scleral fibroblasts
2. Increased latent gelatinase activity in the sclera of visually deprived chicks
3. Form-deprivation myopia induces activation of scleral matrix metalloproteinase-2 in tree shrew
4. Scleral matrix metalloproteinases, serine proteinase activity and hydrational capacity are increased in myopia induced by retinal image degradation
5. Proteoglycan turnover in the sclera of normal and experimentally myopic chick eyes
6. Changes of expression in matrix metalloproteinase and its inhibitor level in the sclera from axially elongated eyes
7. 2α in response to cyclic mechanical stretching
8. Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching
9. Intracellular calcium response to hydraulic pressure in human trabecular cells
10. Stretch-induced expression of genes for remodeling proteins in adult and fetal human scleral fibroblast