Capsazepine, a vanilloid receptor antagonist, inhibits the expression of inducible nitric oxide synthase gene in lipopolysaccharide-stimulated RAW264.7 macrophages through the inactivation of nuclear transcription factor-kappa B

International Immunopharmacology

Volumn 1, Issue 4, 2001, Pages 777-784

  Oh, Gi Su ^a   Pae, Hyun Ock ^a   Seo, Won Gil ^a   Kim, Na Young ^a   Pyun, Kwang Ho ^b   Kim, Il Kwang ^a   Shin, Min kyo ^a   Chung, Hun Taeg ^a,c  

^a Wonkwang University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Wonkwang University School of Medicine   (South Korea)

Author keywords

Capsaicin; Capsazepine; Inducible nitric oxide synthase; Nitric oxide; Nuclear transcription factor kappa B

Indexed keywords

CAPSAICIN; CAPSAZEPINE; NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR; VANILLOID RECEPTOR;

ANIMAL CELL; ARTICLE; CELL VIABILITY; ELECTROPHORETIC MOBILITY; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GENE INACTIVATION; IMMUNOMODULATION; MACROPHAGE ACTIVATION; MEDIATOR RELEASE; MESSENGER RNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CAPSAICIN; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RECEPTORS, DRUG; RNA, MESSENGER;

EID: 0035102231     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(01)00012-1     Document Type: Article

References (47)

1. Regulation of inducible nitric oxide synthase gene expression in vascular smooth muscle cells
2. Endothelin as a regulator of cardiovascular function in health and disease
3. The nitric oxide/cyclic GMP pathway: A potential major regulator of cochlear physiology
4. N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats
5. Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
6. Prostaglandin E2 affects differently the release of inflammatory mediators from resident macrophages by LPS and muramyl tripeptides
7. Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappa B activation
8. Deregulation of cyclooxygenase and nitric oxide synthase gene expression in the inflammatory cascade triggered by experimental group B streptococcal meningitis in the newborn brain and cerebral microvessels
9. Transcription factor nuclear factor kappaB regulates the inducible expression of the human B1 receptor gene in inflammation
10. Activation of the NF-kappa B pathway by inflammatory stimuli in human neutrophils
11. Influence of pyrrolidine dithiocarbamate on the inflammatory response in macrophages and mouse endotoxin shock
12. Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes
13. Immunoglobulin-E/dinitrophenyl complexes induce nitric oxide synthesis in rat peritoneal macrophages by a mechanism involving CD23 and NF-kappa B activation
14. Procyanidins in crataegus extract evoke endothelium-dependent vasorelaxation in rat aorta
15. A novel cGMP-dependent protein kinase from Paramecium
16. Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: Comparison with arachidonic acid-induced ear oedema
17. Substance P provokes cutaneous erythema and edema through a histamine-independent pathway
18. Novel natural vanilloid receptor agonists: New therapeutic targets for drug development
19. Immunocytochemical localization of the vanilloid receptor 1 (VR1): Relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites
20. Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism
21. A possible role of nitric oxide formation in the vasodilatation of rabbit ear artery induced by a topically applied capsaicin analogue
22. The stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety
23. Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids
24. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
25. Stimulation of dichlorofluorescin oxidation by capsaicin and analogues in RAW 264 monocyte/macrophages: Lack of involvement of the vanilloid receptor
26. Inhibition of rapid heat responses in nociceptive primary sensory neurons of rats by vanilloid receptor antagonists
27. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
28. Anandamide transport inhibition by the vanilloid agonist olvanil
29. Stimulation of airway sensory nerves by cyclosporin A and FK506 in guinea pig isolated bronchus
30. Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture
31. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages
32. Dependence of NF-kappaB activation and free radical generation on silica-induced TNF-alpha production in macrophages
33. Kappa B binding activity in a murine macrophage-like cell line. Sequence-specific differences in kappa B binding and transcriptional activation functions
34. Effects of different natriuretic peptides on nitric oxide synthesis in macrophages
35. Progesterone inhibits inducible nitric oxide synthase gene expression and nitric oxide production in murine macrophages
36. Synergistic activation of NF-kappab and inducible isoform of nitric oxide synthase induction by interferon-gamma and tumor necrosis factor-alpha in INS-1 cells
37. Inducible nitric oxide: An autoregulatory feedback inhibitor of vascular inflammation
38. Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation
39. Protein kinase C activation inhibits cytokine-induced nitric oxide synthesis in vascular smooth muscle cells
40. Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells
41. A critical role for nitric oxide in intestinal barrier function and dysfunction
42. Cardiopulmonary dysfunction during porcine endotoxin shock is effectively counteracted by the endothelin receptor antagonist bosentan
43. Prevention of endotoxin shock by an antibody against leukocyte integrin beta 2 through inhibiting production and action of TNF
44. Neuroendocrine defence in endotoxin shock (a review)
45. Signal transduction in esophageal and LES circular muscle contraction
46. Anti-inflammatory action of type I interferons deduced from mice expressing interferon beta
47. Methylprednisolone inhibition of TNF-alpha expression and NF-kB activation after spinal cord injury in rats