The synthesis of the glucuronide metabolite of UK-157,147 using immobilised uridine 5′-diphosphoglucuronyl transferase and traditional organic chemistry techniques (imidate method)

Biocatalysis and Biotransformation

Volumn 19, Issue 1, 2001, Pages 69-83

  Webster, R ^a   Beaumont, K ^a   Ritzau, M ^a   Stachulski, A V ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b UFC Ltd Synergy House   (United Kingdom)

Author keywords

Biocatalysis; Glucuronide; Imidate method

Indexed keywords

1 [[6 (3 HYDROXYPHENYL) SULFONYL] 2,2,3 TRIMETHYL 4 (2 METHYL 3 OXO 2,3 DIHYDROPYRIDAZIN 6 YLOXY) 3 CHROMANOL 3' YL] BETA D GLUCOPYRANOSIDURONIC ACID; BETA GLUCURONIDASE; DRUG METABOLITE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; POTASSIUM CHANNEL STIMULATING AGENT; UK 157147; UK 179094; UK 308013; UNCLASSIFIED DRUG; [6 (3 HYDROXYPHENYL) SULFONYL] 2,2,3 TRIMETHYL 4 (2 METHYL 3 OXO 2,3 DIHYDROPYRIDAZIN 6 YLOXY) 3 CHROMANOL;

ANIMAL TISSUE; ARTICLE; BIOCATALYST; BIOREACTOR; DOG; DRUG ACTIVITY; DRUG CLEARANCE; DRUG DESIGN; DRUG DETERMINATION; DRUG METABOLISM; DRUG PURITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME IMMOBILIZATION; IMMUNOASSAY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC CHEMISTRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION;

ANIMALIA; CANIS FAMILIARIS;

EID: 0035100490     PISSN: 10242422     EISSN: None     Source Type: Journal    
DOI: 10.3109/10242420109103517     Document Type: Article

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