Effect of ipratropium bromide on airway and pulmonary muscarinic receptors in a rat model of chronic obstructive pulmonary disease

Chinese Medical Journal

Volumn 114, Issue 1, 2001, Pages 80-83

  Yao, Wanzhen ^a   Wang, Guoyang ^a   Zhu, Hong ^a   Sun, Yongchang ^a   Zhao, Mingwu ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Animal model; Chronic obstructive pulmonary disease; Muscarinic; Receptor

Indexed keywords

IPRATROPIUM BROMIDE; MUSCARINIC RECEPTOR; SULFUR DIOXIDE;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG RECEPTOR BINDING; LIGAND BINDING; LUNG PARENCHYMA; MALE; NONHUMAN; PATHOPHYSIOLOGY; RAT; RECEPTOR DENSITY;

ANIMALS; BRONCHODILATOR AGENTS; DISEASE MODELS, ANIMAL; IPRATROPIUM; LUNG; MALE; MUSCARINIC ANTAGONISTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RATS; RATS, WISTAR; RECEPTORS, MUSCARINIC; SULFUR DIOXIDE; TRACHEA;

EID: 0035097874     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Shore SA, Kobzik L, Long NC, et al. Increased airway responsiveness to inhaled methacholine in a rat model of chronic brondhitis. Am J respir Crit Care Med 1995;151:1931-1938.
2. Chiba Y, Misawa M. Characteristic of muscarinic cholinoceptors in airways of antigen-induced airway hyperresponsive rats. Comp Biochem Physiol 1995;111:351-357.
3. Raaijimakers JAM, Terpstra GK, Witter A, et al. Muscarinic cholinergic receptors in peripheral lung tissue of normal subjects and of patients with chronic obstructive lung disease. Clin Sci 1983;66:585-590.
4. Koppen VJC, Miranda JFRD, Beld AJ, et al. Muscarinic receptor sensitivity in airway smooth muscle of patients with obstructive airway disease. Arch Int Pharmacodyn 1988;295:238-244.
5. Barnes PJ. Modulation of neurotransmission in airways. Physiol Rev 1992;72:699-729.
6. Zaagsma J, Roffel AF. Muscarinic inhibitory autoreceptors in different generations of human airways. Am J Respir Crit Care Med 1996;154:43-49.
7. Ikeda A, Nishimura K, Koyama H, et al. Bronchodilating effects of combined therapy with clinical dosages of ipratropium bromide and salbutamol for stable COPD: comparison with ipratropium bromide alone. Chest 1995;107:401-405.
8. Newcomb R, Tashkin DP, Hui KK, et al. Rebound hyperresponsiveness to muscarinic stimulation after chronic therapy with an inhaled muscarinic antagonist. Am Rev Respir Dis 1985;132:12-15.
9. Wilding PJ, Clark MM, Pavord ID, et al. Effect of cessation of short-term therapy with ipratropium bromide on lung function and airway responsiveness. Eur Respir J 1996;9:1627-1631.
10. Vaughan TR, Bowen RE, Goodman DL, et al. The development of subsensitivity to atropine methylnitrate. Am Rev Respir Dis 1988;138:771-774.