Gut luminal neutrophil migration is influenced by the anatomical site of crohn’s disease

European Journal of Gastroenterology and Hepatology

Volumn 13, Issue 3, 2001, Pages 239-243

  Arnott, Ian D R ^a   Drummond, Hazel E ^a   Ghosh, Subrata ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Crohn s disease; Granulocyte elastase; Gut bacterial flora; Interleukin 1 ; Interleukin 8; Whole gut lavage; Whole gut lavage fluid

Indexed keywords

ELASTASE;

ADULT; ARTICLE; COLON CROHN DISEASE; DIFFERENTIAL DIAGNOSIS; DISEASE ACTIVITY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTESTINE LAVAGE; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL CHEMOTAXIS; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADULT; CHEMOTAXIS, LEUKOCYTE; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-8; INTESTINE, LARGE; INTESTINE, SMALL; IRRIGATION; LEUKOCYTE ELASTASE; MALE; MIDDLE AGED; NEUTROPHILS;

EID: 0035097038     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/00042737-200103000-00004     Document Type: Article

References (29)

1. Mekhjian HS, Switz DM, Melnyk CS, Rankin GB, Brooks RK. Clinical features and natural history of Crohn’s disease (NCCDS). Gastroenterology 1979; 77: 898-906.
2. Steinhardt HJ, Loeschke K, Kasper H, Holtermuller KH, Schafer H. European Cooperative Crohn’s Disease Study (ECCDS): clinical features and natural history. Digestion 1985; 31: 97-108.
3. Sahmound T, Hoctin-Boes G, Modigliani R, Bitoun A, Colombel JF, Soule JC. et al. Identifying patients with a high risk of relapse in quiescent Crohn’s disease. Gut 1995; 37: 811-818.
4. Verspaget HW, Pena AS, Weterman IT, Lamers CBHW. Diminished neutrophil function in Crohn’s disease and ulcerative colitis identified by decreased oxidative metabolism and low superoxide dismutase content. Gut 1988; 29: 223-228.
5. Choudari CP, O’Mahony S, Brydon G, Mwantembe O, Ferguson A. Gut lavage protein concentrations: objective measures of disease activity in inflammatory bowel disease. Gastroenterology 1990; 99: 1380-1387.
6. Brydon WG, Ferguson A. Haemoglobin in gut lavage as a measure of gastrointestinal blood loss. Lancet 1992; 340: 1381-1382.
7. Handy LM, Ghosh S, Ferguson A. Investigation of neutrophil migration into the gut by cytology of whole gut lavage fluid. Eur J Gastroenterol Hepatol 1995; 7: 53-58.
8. Handy LM, Ghosh S, Ferguson A. Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole gut lavage fluid. Scand J Gastroenterol 1996; 31: 700-705.
9. Pullman WE, Elsbury S, Kobayashi M, Hapel AJ, Doe WF. Enhanced mucosal cytokine production in inflammatory bowel disease. Gastroenterology 1992; 102: 529-537.
10. Mitsuyama K, Toyonaga A, Sasaki E, Watanabe K, Tateishi H, Nishiyama T. et al. IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn’s disease. Clin Exp Immunol 1994; 96: 432-436.
11. Troncone R, Caputo N, Campanozzi A, Cucciardi M, Esposito V, Russo R. et al. Gut lavage IgG and interleukin 1 receptor antagonist:interleukin 1β ratio as markers of intestinal inflammation in children with inflammatory bowel disease. Gut 1997; 41: 60-65.
12. Croft NM, Marshall TG, Ferguson A. Gut inflammation in children with cystic fibrosis on high-dose enzyme supplements. Lancet 1995; 346: 1265-1267.
13. Sigthorsson G, Tibble J, Hayllar J, Menzies I, MacPherson A, Moots R. et al. Intestinal permeability and inflammation in patients on NSAIDs. Gut 1998; 43: 506-511.
14. Kramps JA, van Twisk C, van der Linden AC. l-Pyroglutamyl- l-propyl- l-valine-p-nitroanilide, a highly specific substrate for granulocyte elastase. Scand J Clin Lab Invest 1983; 43: 427-432.
15. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993; 75: 253-261.
16. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-274.
17. D’Haens GR, Geboes K, Peeters M, Baert F, Penninckx F, Rutgeerts P. Early lesions of recurrent Crohn’s disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 1998; 114: 262-267.
18. O’Mahony S, Choudari CP, Barton JR, Walker S, Ferguson A. Gut lavage fluid proteins as markers of activity of inflammatory bowel disease. Scand J Gastroenterol 1991; 26: 940-944.
19. Acciuffi S, Ghosh S, Ferguson A. Strengths and limitations of the Crohn’s disease activity index, revealed by an objective gut lavage test of gastrointestinal protein loss. Aliment Pharmacol Ther 1997; 10: 321-326.
20. Levy AM, Gleich GJ, Sandborn WJ, Tremaine WJ, Steiner BL, Phillips SF. Increased eosinophil granule proteins in gut lavage fluid from patients with inflammatory bowel disease. Mayo Clin Proc 1997; 72: 117-123.
21. Hommes DW, Meenan J, de Haas M, ten Kate FJ, von dem Borne AE, Tytgat GN. et al. Soluble Fc gamma receptor III (CD 16) and eicosanoid concentrations in gut lavage fluid from patients with inflammatory bowel disease: reflection of mucosal inflammation. Gut 1996; 38: 564-567.
22. Klapproth J-M, Donnenberg MS, Abraham JM, Mobley HLT, James SP. Products of enteropathogenic E. coli inhibit lymphocyte activation and lymphokine production. Infect Immun 1995; 63: 2248-2254.
23. Baggiolini M, Walz A, Kunkel SL. Neutrophil activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 1989; 84: 1045-1049.
24. Hermanowicz A, Gibson PR, Jewell DP. The role of phagocytes in inflammatory bowel disease. Clin Sci 1985; 69: 241-249.
25. Madara JL. Review article: Pathobiology of neutrophil interactions with intestinal epithelia. Aliment Pharmacol Ther 1997; 11: 57-63.
26. Saverymuttu SH, Peters AM, Lavender JP, Pepys MB, Hodgson HJF, Chadwick VS. Quantitative fecal indium 111-labeled leukocyte excretion in the assessment of disease in Crohn’s disease. Gastroenterology 1983; 85: 1333-1339.
27. Saverymuttu SH. Clinical remission in Crohn’s disease- assessment using faecal 111-In granulocyte excretion. Digestion 1986; 33: 74-79.
28. Teahon K, Smethurst P, Pearson M, Levi AJ, Bjarnason I. The effect of elemental diet on intestinal permeability and inflammation in Crohn’s disease. Gastroenterology 1991; 101: 84-89.
29. Saverymuttu SH, Camilleri M, Rees H, Lavender JP, Hodgson HJF, Chadwick VS. Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. Gastroenterology 1986; 90: 1121-1128.