Toxicity of 2,6-Di-tert-butyl-4-Nitrophenol (DBNP)

Applied Occupational and Environmental Hygiene

Volumn 16, Issue 4, 2001, Pages 487-495

  Alexander, William K ^a   Briggs, G Bruce ^b   Still, Kenneth R ^a   Jederberg, Warren W ^c   MacMahon, K ^d   Baker, W H ^d   MacKerer, C ^e  

^a WRIGHT PATTERSON AIR FORCE BASE   (United States)

^b SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

^c Commander Submarine Force ^*  (United States)

^d AIR FORCE RESEARCH LABORATORY   (United States)

^e EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

Author keywords

DBNP; DBNP Toxicity; DBP; Submarine

Indexed keywords

4 NITROPHENOL; PHTHALIC ACID DIBUTYL ESTER;

AIRBORNE PARTICLE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; LD 50; MALE; NAVY; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; OCCUPATIONAL SAFETY; OCCUPATIONAL TOXICOLOGY; PRIORITY JOURNAL; RAT; SKIN ABSORPTION; UNITED STATES;

ANIMALS; DERMATITIS, IRRITANT; DINITROPHENOLS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; FEMALE; LETHAL DOSE 50; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RABBITS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; RISK FACTORS; SUBMARINE MEDICINE; UNCOUPLING AGENTS;

EID: 0035094028     PISSN: 1047322X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10473220117206     Document Type: Article

References (12)

1. General Dynamics/Electric Boat Division Report: Submarine Yellowing Problem, 9510/61-225-X-2, 6110/429. (1992) Unpublished.
2. Vesselinovitch, D., Dubois, K.P., Fitch, F.W., Doull, J.: Mammalian Toxicity and Histopathologic Effects of 2,6- Dibutyl-4-Nitrophenol. Toxicol Appl Pharmacol 3:713–725 (1961).
3. Holder, G.M., Ryan, A.J., Watson, T.R., Wiebe, L.I.: A Note on the Excretion of 2,6-Di-tert-butyl-4-nitrophenol. Food Cosmet Toxicol 9:531–535 (1970).
4. MacMahon, K.L., Baker, W.H., Alexander, W.K., Jederberg, W.W., Still, K.R., Briggs, G.B., Godfrey, R.J.: Acute Oral and Dermal Toxicity Evaluation of 2,6-Dibutyl-4-nitrophenol. Air Force Research Laboratory Technical Report AFRL/HEST-TR-1998. AFRL/HEST, (in press).
5. MacMahon, K.L., Baker, W.H., Alexander, W.K., Still, K.R., Briggs, G.B., Godfrey, R.J.: Acute Oral Toxicity Evaluation of 2,6-Dibutyl-4-nitrophenol in Sprague-Dawley Rats. Air Force Research Laboratory Technical Report AFRL/HEST-TR-1999. AFRL/HEST, (in press).
6. Carpenter, R.L., Narayanan, T.K., Jung, A.E., Prues, S., Still, K.R.: Characterization of the Metabolism, Distribution and Toxicity of 2,6-Di-t-Butyl-4-Nitrophenol. Naval Medical Research Institute Technical Report No. NMRI-97-39. Naval Medical Research Institute, (1997).
7. Stryer, L.: Biochemistry, 4th ed. W.H. Freeman and Company, (1995).
8. Klingenberg, M.: Mechanism and Evolution of the Uncoupling Protein of Brown Adipose Tissue. Trends Biochem Sci 15:108–112 (1990).
9. Rivera-Nevares, J.A., Wyman, J.F., Von Minden, D.L., Lacy, N., Chabinyc, M.L., Fratini, A.V., Macys, D.A.: Facile Synthesis and Physical and Spectral Characterization of 2,6-Di-tert-Butyl-4- Nitrophenol, APotentially Powerful Uncoupler of Oxidative Phosphorylation. Env Tox Chem 14(2):251–256 (1995).
10. Barnes, D. G., Dourson, M.: Reference Dose (RfD): Description and Use in Health Risk Assessments. Reg Toxicol Pharmacol 8:471–486 (1988).
11. World Health Organization: Principles Governing Consumer Safety in Relation to Pesticide Residues, WHO Tech Rep. Ser. WHO, Geneva (1962).
12. Lu, F.C.: Acceptable Daily Intake: Inception, Evolution, and Application. Reg Toxicol Pharmacol 8:45–60 (1988).