NO involvement in mediation of spinal neuron sensitization in morphine-withdrawal rats

Acta Physiologica Sinica

Volumn 53, Issue 1, 2001, Pages 75-78

  Cao, Jun Li ^a   Zeng, Yin Ming ^b   Zhang, Li Cai ^b   Gu, Jun ^c   Zhou, Wen Hua ^c   Yang, Guo Dong ^c  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b Jiangsu Institute of Anesthesiology   (China)

^c Ningbo Addiction Research and Treatment Center   (China)

Author keywords

Fos protein; Morphine; NO; Sensitization; Spinal cord; Withdrawal

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MORPHINE; NALOXONE; NITRIC OXIDE; PROTEIN FOS; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG WITHDRAWAL; IMMUNOCYTOCHEMISTRY; MORPHINE ADDICTION; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; SENSITIZATION; SPINAL CORD NERVE CELL; WITHDRAWAL SYNDROME;

ANIMALS; MALE; MORPHINE; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0035093604     PISSN: 03710874     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Hayward MD, Duman RS, Nestler EJ. Induction of the c-fos protooncogene during opiate withdrawal in the locus coeruleus and other region of the brain. Brain Res , 1990, 525: 256-266.
2. Bozarth MA. Physical dependence produced by central morphine infusion : An anatomical mapping study. Neurosci Biohav Rev, 1994, 18: 373-383.
3. Jhamandas JH, Harris KH, Petrov T. Activation of nitric oxide-synthesizing neurons during precipitated morphine withdrawal. Neuroreport, 1996, 7: 2843-2846.
4. Dunber SA, Pulai LJ. Repetitive opioid abstinence causes progressive hyperalgesia sensitive to N-methl-D-aspartate receptor in the rat. J Pharmac Exp Ther, 1998, 284: 678-686.
5. Rohde DS, Detweiler DJ, Bashaum AI et al. Formalin-evoked fos expressing is enhanced in morphine-tolerant rats. Brain Res, 1997, 766: 93-100.
6. Cao JL, Zeng YM, Zhang LC et al. Increased expression of formalin- induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats. Acta Physiol Sin, 2000, 52 (3): 235-238 (Chinese, English abstract).
7. Wang H, An XM, Zhang RX et al. C-Fos- and NMDA receptor-like immunoreactive neurons in spinal cord following peripheral formalin injection: a double immunocytochemical study in rats. Chin J Neurosci , 1999, 15 (2): 96-102 (English, Chinese abstract).
8. Guen SL, Catheline C, Besson JM. Development of tolerance to the antinociceptive effect of systemic morphine at the lumbar spinal cord level: a c-Fos study in the rat. Brain Res, 1998, 813: 128-138.
9. Atewh SM, Kuhar MJ. Autoradiographic location of opiate receptor in rat brain. I . Spinal cord and lower medulla. Brain Res, 1977, 124: 53-67.
10. Cuellar B, Fernandez AP, Lizasoain I et al. Up-regulation of neuronal NO synthase immunoreactivity in opiate dependence and withdrawal. Psychopharmacology, 2000, 148: 66 -73.
11. Medvedev IO, Dravolina OA, Bespalov AY. Differential effects of nitric oxide synthase inhibitor, 7-nitroindazole, on discriminative stimulus and somatic effects of naloxone in morphine-dependent rats. Eur J Pharmacol, 1999, 377: 183-186.
12. Machelska H, Ziolkowska B, Mika J et al. Chronic morphine increases biosynthesis of nitric oxide syntheses in the rat spinal cord. Neuroreport, 1997, 8: 2743-2747.