Power consumption profiles in high-shear wet granulation. II: Predicting the overwetting point from a spreading energy

Journal of Pharmaceutical Sciences

Volumn 90, Issue 3, 2001, Pages 332-339

  Cleland, Jeffrey L ^a   Lam, Xanthe ^a   Kendrick, Brent ^b   Yang, Janet ^a   Yang, Tzung Horng ^c   Overcashier, David ^a   Brooks, Dennis ^a   Hsu, Chung ^a   Carpenter, John F ^c  

^a GENENTECH INC   (United States)

^b AMGEN INC   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Contact angles; Endpoint; Power consumption; Spreading energy; Surface tension; Wet granulation

Indexed keywords

ANTIBIOTIC AGENT; LACTOSE; MAGNESIUM STEARATE;

ARTICLE; CONTACT ANGLE; DRUG GRANULATION; ENERGY; MODEL; POWDER; PREDICTION; PROCESS CONTROL; SURFACE TENSION; WETTABILITY;

EID: 0035092970     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200103)90:3<332::AID-JPS8>3.0.CO;2-D     Document Type: Article

References (10)

1. Power consumption in high-shear granulation. I: Liquid distribution in relation to powder and binder properties
2. Endpoint determination and its relevance to physicochemical characteristics of solid dosage forms
3. Mechanism and end-point of agitation granulator
4. Granulations with surfactants: Effects on pasting
5. Binder-substrate interactions in granulation: A theoretical approach based on surface free energy and polarity
6. An assessment of substrate-binder interactions in model wet masses. 1: Mixer torque rheometry
7. Powder dynamic contact angle measurements: Young contact angles and effectively wet perimeters
8. Critique of the friction coefficient concept for wet (lubricated) sliding
9. Force transmission in granular media