Pharmacokinetics of netobimin and microsomal metabolism of albendazole in infected gerbils with Echinococcus granulosus

Parasitology Research

Volumn 87, Issue 2, 2001, Pages 107-111

  Garcia Llamazares J L ^a   Merino Pelaez, G ^a   Larrode Pellicer, O ^a   Redondo Cardena P A ^a   Prieto Fernandez J G ^a   Alvarez De Felipe, A I ^a  

^a UNIVERSITY OF LEÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE SULFONE; ALBENDAZOLE SULFOXIDE; INTESTINE ENZYME; LIVER ENZYME; MEBENDAZOLE; NETOBIMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG TRANSFORMATION; ECHINOCOCCOSIS; ECHINOCOCCUS GRANULOSUS; ENZYME ACTIVITY; FEMALE; GERBIL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL;

ALBENDAZOLE; ANIMALS; ANTICESTODAL AGENTS; DISEASE MODELS, ANIMAL; ECHINOCOCCOSIS; ECHINOCOCCUS; GERBILLINAE; GUANIDINES; MICROSOMES;

ANIMALIA; CESTODA; ECHINOCOCCUS GRANULOSUS; GERBILLINAE; MERIONES UNGUICULATUS; OVIS ARIES;

EID: 0035091851     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360000309     Document Type: Article

References (25)

1. Regulation of cytochrome P450:Effects of two-thirds hepatectomy, cholestasis, biliary cirrhosis and post-necrotic cirrhosis on hepatic and renal microsomal enzymes
2. The absorption, distribution and elimination of anthelmintic drugs: The role of pharmacokinetics
3. Comparison of hepatic and extrahepatic drug-metabolizing enzyme activities in rats given single or multiple challenge infections with Fasciola hepatica
4. Incidence of experimental coccidiosis on the activity of microsomal drug metabolizing enzymes in rabbit liver
5. Netobimin (totabin-SCH):Preliminary investigations on metabolism and pharmacology
6. Comparison of the effects of inducers of cytochrome P450 on Mongolian gerbil and rat hepatic microsomal monooxygenase activities
7. In vitro sulfoxidation of albendazole by ovine liver microsomes: Assay and frequency of various xenobiotics
8. In vivo inhibition of the regenerative capacity of hydatid material after treatment with netobimin
9. Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants
10. Gastrointestinal distribution of albendazole metabolites following netobimin administration to cattle: Relationship with plasma disposition kinetics
11. Protein measurement with the folin phenol reagent
12. Effect of parasitism with Nematodirus battus on the pharmacokinetics of levamisole, ivermectin and netobimin
13. Plasma profiles of albendazole metabolites after administration of netobimin and albendazole in sheep: Effects of parasitism and age
14. Chiral sulfoxidation of albendazole by the ravin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes
15. Albendazole-objective evidence of response in human hydatid disease
16. Penetration of albendazole sulphoxide into hydatid cysts
17. Influence of surfactants on oral bioavailability of albendazole based on the formation of the sulphoxide metabolites in rats
18. The propagation of secondary cysts of Echinococcus granulosus in the mongolian jird. Meriones unguiculatus
19. PKCALC: A basic interactive computer program for statistical and pharmacokinetic analysis of data
20. Altered drug metabolism in parasitic diseases
21. The mongolian gerbil (Meriones unguiculatus) as a laboratory host for the cystic stage of Echinococcus granulosus of British horse origin
22. Small intestinal sulphoxidation of albendazole
23. Pharmacokinetics of an anthelmintic potential prodrug of a new benzimidazole in gerbil, mouse and sheep
24. Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation