Coincidence, coevolution, or causation? DNA content, cellsize, and the C-value enigma

Biological Reviews

Volumn 76, Issue 1, 2001, Pages 65-101

  Gregory, T Ryan ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

C value paradox; Cell cycle; Evolution; Genome size; Junk DNA; Nucleoskeleton; Nucleotype; Repetitive elements; Selfish DNA; Transposable elements

Indexed keywords

DNA;

CELL CYCLE; CELL SIZE; CELL VOLUME; DNA CONTENT; EVOLUTION; MUTATION; NONHUMAN; REVIEW; TRANSPOSON;

ANIMALS; CELL SIZE; DNA; EVOLUTION, MOLECULAR; GENOME; HUMANS; MODELS, GENETIC;

EUKARYOTA;

EID: 0035090476     PISSN: 14647931     EISSN: 1469185X     Source Type: Journal    
DOI: 10.1111/j.1469-185X.2000.tb00059.x     Document Type: Article

References (260)

1. Awadalla, P., Eyre-Walker, A. & Maynard Smith, J. (1999). Linkage disequilibrium and recombination in hominid mitochondrial DNA. Science 286, 2524–2525.
2. Bachmann, K., Chambers, K.L. & Price, H. J. (1985). Genome size and natural selection: Observations and experiments in plants. In The Evolution of Genome Size (ed. T. Cavalier-Smith), pp. 267–276. John Wiley & Sons, Chichester, UK.
3. Baker, R. J., Maltbie, M., Owen, J. G., Hamilton, M. J. & Bradley, R. D. (1992). Reduced number of ribosomal sites in bats: Evidence for a mechanism to contain genome size. Journal of Mammalogy 73, 847–858.
4. Banditt, M., Koller, T. & Sogo, J. M. (1999). Transcriptional activity and chromatin structure of enhancer-deleted rRNA genes in Saccharomyces cerevisiae. Molecular and Cellular Biology 19, 4953–4960.
5. Beaton, M. J. (1995). Patterns of endopolyploidy and genome size variation in Daphnia. Ph.D. Thesis, University of Guelph, Guelph, Ontario.
6. Beaton, M. J. & Hebert, P. D. N. (1989). Miniature genomes and endopolyploidy in cladoceran crustaceans. Genome 32, 1048–1053.
7. Beaton, M. J. & Cavalier-SMITH, T. (1999). Eukaryotic noncoding DNA is functional: Evidence from the differential scaling of cryptomonad genomes. Proceedings of the Royal Society of London, Series B 266, 2053–2059.
8. Becak, W., Becak, M. L., Lavalle, D. & Schreiber, G. (1967). Further studies on polyploid amphibians (Ceratophrydidae). Ii. Dna content and nuclear volume. Chromosoma 23, 14–23.
9. Beerman, S. (1977). The diminution of heterochromatic chromosomal segments in Cyclops (Crustacea, Copepoda). Chromosoma 60, 297–344.
10. Bemis, W. E. (1984). Paedomorphosis and the evolution of the Dipnoi. Paleobiology 10, 293–307.
11. Bennett, M. D. (1971). The duration of meiosis. Proceedings of the Royal Society of London, Series B 178, 277–299.
12. Bennett, M. D. (1972). Nuclear DNA content and minimum generation time in herbaceous plants. Proceedings of the Royal Society of London, Series B 181, 109–135.
13. Bennett, M. D. (1973). Nuclear characters in plants. Brookhaven Symposia in Biology 25, 344–366.
14. Bennett, M. D. (1982). Nucleotypic basis of the spatial ordering of chromosomes in eukaryotes and the implications of the order for genome evolution and phenotypic variation. In Genome Evolution (ed. G. A. Dover & R. B. Flavell), pp. 239–261. Academic Press, New York.
15. Bennett, M. D. (1985). Intraspecific variation in DNA amount and the nucleotypic dimension in plant genetics. In Plant Genetics (ed. M. Freeling), pp. 283–302. Alan R. Liss, New York.
16. Bennett, M. D. (1987). Variation in genomic form in plants and its ecological interpretation. New Phytologist 106 (Supplement), 177–200.
17. Bennett, M. D. (1996). The nucleotype, the natural karyotype and the ancestral genome. Symposia of the Society for Experimental Biology 50, 45–52.
18. Bennett, M. D., Chapman, V. & Riley, R. (1971). The duration of meiosis in pollen mother cells of wheat, rye and Triticale. Proceedings of the Royal Society of London, Series B 178, 259–275.
19. Bennett, M. D. & Smith, J. B. (1972). The effects of polyploidy on meiotic duration and pollen development in cereal anthers. Proceedings of the Royal Society of London, Series B 181, 259–275.
20. Bernardi, G. (1993). The vertebrate genome: Isochores and evolution. Molecular Biology and Evolution 10, 186–204.
21. Bernardi, G. (2000). Isochores and the evolutionary dynamics of vertebrates. Gene 241, 3–17.
22. Biderre, C., Pages, M., Metenier, G., Canning, E.U. & Vivares, C. P. (1995). Evidence for the smallest nuclear genome (2.9 Mb) in the microsporidium Encephalitozoon cuniculi. Molecular and Biochemical Parasitology 74, 229–233.
23. Biradar, D. P., Bullock, D.G. & Rayburn, A. L. (1994). Nuclear DNA amount, growth and yield parameters in maize. Theoretical and Applied Genetics 88, 557–560.
24. Bird, A. P. (1995). Gene number, noise reduction and biological complexity. Trends in Genetics 11, 94–100.
25. Bradbury, E. M., Inglis, R. J., Matthews, H.R. & Langan, T. A. (1974). Molecular basis of control of mitotic cell division in eukaryotes. Nature 249, 553–556.
26. Bradley, M. V. (1954). Cell and nuclear size in relation to polysomaty and the nuclear cycle. American Journal of Botany 41, 398–402.
27. Brodsky, V. Ya. & Uryvaeva, I. V. (1985). Genome Multiplication in Growth and Development. Cambridge University Press, Cambridge, UK.
28. Brosius, J. (1999). RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements. Gene 238, 115–134.
29. Brown, D.D. & Dawid, I. B. (1968). Specific gene amplification in oocytes. Oocyte nuclei contain extrachromosomal replicas of the genes for ribosomal RNA. Science 160, 272–280.
30. Caceres, M. E., De Pace, C., Scarascia Mugnozza, G. T., Kotsonis, P., Ceccarelli, M. & Cionini, P. G. (1998). Genome size variations within Dasypyrum villosum: Correlations with chromosomal traits, environmental factors and plant phenotypic characteristics and behaviour in reproduction. Theoretical and Applied Genetics 96, 559–567.
31. Cavalier-Smith, T. (1978). Nuclear volume control by nucleoskeletal DNA, selection for cell volume and cell growth rate and the solution of the DNA C-value paradox. Journal of Cell Science 34, 247–278.
32. Cavalier-Smith, T. (1980a). How selfish is DNA Nature 285, 617–618.
33. Cavalier-Smith, T. (1980b). r- and K-tactics in the evolution of protist developmental systems: Cell and genome size, phenotype diversifying selection and cell cycle patterns. BioSystems 12, 43–59.
34. Cavalier-Smith, T. (1982). Skeletal DNA and the evolution of genome size. Annual Review of Biophysics and Bioengineering 11, 273–302.
35. Cavalier-Smith, T. (1985a). Introduction: The evolutionary significance of genome size. In The Evolution of Genome Size (ed. T. Cavalier-Smith), pp. 1–36. John Wiley & Sons, Chichester, UK.
36. Cavalier-Smith, T. (1985b). Cell volume and the evolution of eukaryote genome size. In The Evolution of Genome Size (ed. T. Cavalier-Smith), pp. 104–184. John Wiley & Sons, Chichester, UK.
37. Cavalier-Smith, T. (1985c). DNA replication and the evolution of genome size. In The Evolution of Genome Size (ed. T. Cavalier-Smith), pp. 211–251. John Wiley & Sons, Chichester, UK.
38. Cavalier-Smith, T. (1985d). Selfish DNA, intragenomic selection and genome size. In The Evolution of Genome Size (ed. T. Cavalier-Smith), pp. 253–265. John Wiley & Sons, Chichester, UK.
39. Cavalier-Smith, T. (1991). Coevolution of vertebrate genome, cell and nuclear sizes. In Selected Symposia and Monographs U. Z. I., Vol. 4. (ed. G. Ghiara et al.), pp. 51–86. Mucchi, Modena.
40. Cavalier-Smith, T. (1993). Evolution of the eukaryotic genome. In The Eukaryotic Genome (ed. P. Brode, S. G. Oliver & P. Sims), pp. 333–385. Cambridge University Press, Cambridge, UK.
41. Cavalier-Smith, T. & Beaton, M. J. (1999). The skeletal function of non-genic nuclear DNA: New evidence from ancient cell chimaeras. Genetica 106, 3–13.
42. Cavallini, A. & Natali, L. (1994). Chromosome endoreduplication variability in cultivars of Pisum sativum L. And its relationship to basic genome size. Cytobios 79, 181–188.
43. Charlesworth, B., Sniegowski, P. & Stephan, W. (1994). The evolutionary dynamics of repetitive DNA in eukaryotes. Nature 371, 215–220.
44. Chang, H.-Y., Sang, T.-K., Jan, K. Y. & Chen, C.-T. (1995). Cellular DNA contents and cell volumes of Batoids. Copeia 1995, 571–576.
45. Chevalier, S. & Blow, J. J. (1996). Cell cycle control of replication initiation in eukaryotes. Current Opinion in Cell Biology 8, 815–821.
46. Chung, J., Lee, J.-H., Arumuganathan, K., Graef, G. L. & Specht, J. E. (1998). Relationships between nuclear DNA content and seed and leaf size in soybean. Theoretical and Applied Genetics 96, 1064–1068.
47. Clark-Walker, G. D. (1985). Basis of diversity in mitochondrial DNAs. In The Evolution of Genome Size (ed. T. Cavalier-Smith), pp. 277–297. John Wiley & Sons, Chichester, UK.
48. Collas, P. (1998). Cytoplasmic control of nuclear assembly. Reproduction Fertility and Development 10, 581–592.
49. Comings, D. E. (1980). Arrangement of chromatin in the nucleus. Human Genetics 53, 131–143.
50. Commoner, B. (1964). Roles of deoxyribonucleic acid in inheritance. Nature 202, 960–968.
51. Cosmides, L.M. & Tooby, J. (1981). Cytoplasmic inheritance and intragenomic conflict. Journal of Theoretical Biology 89, 83–129.
52. Craigie, R. (1992). Hotspots and warm spots: Integration specificity of retroelements. Trends in Genetics 8, 187–190.
53. Csink, A. & Henikoff, S. (1996). Genetic modification of heterochromatic association and nuclear organization in Drosophila. Nature 381, 529–531.
54. Cui, K. (1997). Size differences between human X and Y spermatozoa and prefertilization diagnosis. Molecular Human Reproduction 3, 61–67.
55. Cullis, C. A. (1986). Phenotypic consequences of environmentally induced changes in plant DNA. Trends in Genetics 2, 307–309.
56. Cullis, C. A. (1990). Dna rearrangements in response to environmental stress. Advances in Genetics 28, 73–97.
57. Dawkins, R. (1982). The Extended Phenotype. Oxford University Press, Oxford, UK.
58. Dawkins, R. (1989). The Selfish Gene, 2nd Ed. Oxford University Press, Oxford, UK.
59. Dernburg, A. F., Broman, K. W., Fung, J. C., Marshall, W. F., Philips, J., Agard, D.A. & Sedat, J. W. (1996). Perturbation of nuclear architecture by long-distance chromosome interactions. Cell 85, 745–759.
60. Dobzhansky, Th. (1929). The influence of the quantity of chromosomal material on the size of the cells in Drosophila melanogaster. Arch. F. Entw. Mech. Org. 115, 363–379.
61. Donachie, W. D. (1968). Relationship between cell size and time of initiation of DNA replication. Nature 219, 1077–1079.
62. Donaldson, A.D. & Blow, J. J. (1999). The regulation of replication origin activation. Current Opinion in Genetics & Development 9, 62–68.
63. Doolittle, W.F. & Sapienza, C. (1980). Selfish genes, the phenotype paradigm and genome evolution. Nature 284, 601–603.
64. Duke, J.T. & Ultsch, G. R. (1990). Metabolic oxygen regulation and conformity during submergence in the salamanders Siren lacertina, Amphiuma means and Amphiuma tridactylum and a comparison with other giant salamanders. Oecologia 84, 16–23.
65. Elder, J. F. & Turner, B. J. (1995). Concerted evolution of repetitive DNA sequences in eukaryotes. Quarterly Review of Biology 70, 297–320.
66. Endow, S. A. & Glover, D. M. (1979). Differential replication of ribosomal gene repeats in polytene nuclei of Drosophila. Cell 17, 597–605.
67. Escribano, R., Mclaren, I. A. & Klein Breteler, W. C.M. (1992). Innate and acquired variation of nuclear DNA contents of marine copepods. Genome 35, 602–610.
68. Evans, G.M. & Rees, H. (1971). Mitotic cycles in dicotyledons and monocotyledons. Nature 233, 350–351.
69. Evans, G. M., Rees, H., Snell, C. L. & Sun, S. (1973). The relationship between nuclear DNA amount and the duration of the mitotic cycle. Chromosomes Today 3, 24–31.
70. Eyre-Walker, A., Smith, N. H. & Maynard Smith, J. (1999A). How clonal are human mitochondria Proceedings of the Royal Society of London, Series B 266, 477–483.
71. Eyre-Walker, A., Smith, N. H. & Maynard Smith, J. (1999B). Reply to Macaulay et al. (1999): Mitochondrial DNA recombination - reasons to panic. Proceedings of the Royal Society of London, Series B 266, 2041–2042.
72. Fankhauser, G. (1955). The role of nucleus and cytoplasm. In Analysis of Development (ed. B. H. Willier, P. A. Weiss & V. Hamburger), pp. 126–150. Saunders, Philadelphia.
73. Felsenstein, J. (1985). Phylogenies and the comparative method. American Naturalist 125, 1–15.
74. Follette, P. J. & O’Farrell, P. H. (1997). Cdks and the Drosophila cell cycle. Current Opinion in Genetics & Development 7, 17–22.
75. Francis, D., Kidd, A.D. & Bennett, M. D. (1985). Dna replication in relation to DNA C values. In The Cell Division Cycle in Plants (ed. J. A. Bryant and D. Francis), pp. 61–82. Cambridge University Press, Cambridge, UK.
76. Futcher, B. (1996). Cyclins and the wiring of the yeast cell cycle. Yeast 12, 1635–46.
77. Galitski, T., Saldanha, A. J., Styles, C. A., Lander, E. S. & Fink, G. R. (1999). Ploidy regulation of gene expression. Science 285, 251–254.
78. Gallardo, M. H., Bickham, J. W., Honeycutt, R. L., Ojeda, R. A. & Köhler, N. (1999). Discovery of tetraploidy in a mammal. Nature 401, 341.
79. Gilbert, D. M. (1998). Replication origins in yeast versus metazoa: Separation of the haves and the have nots. Current Opinion in Genetics & Development 8, 194–199.
80. Gilson, P. R. & Mcfadden, G. I. (1997). Good things in small packages: The tiny genomes of chlorarachniophyte endosymbionts. Bioessays 19, 167–173.
81. Gilson, P. R., Maier, U.-G. & Mcfadden, G. I. (1997). Size isn’t everything: Lessons in genetic miniaturisation from nucleomorphs. Current Opinion in Genetics & Development 7, 800–806.
82. Gould, S. J. (1996). Full House. Harmony Books, New York.
83. Gould, S. J. & Lewontin, R. C. (1979). The spandrels of San Marco and the Panglossian paradigm: A critique of the adaptationist programme. Proceedings of the Royal Society of London, Series B 205, 581–598.
84. Gould, S. J. & Vrba, E. S. (1982). Exaptation - a missing term in the science of form. Paleobiology 8, 4–15.
85. Grafi, G. (1998). Cell cycle regulation of DNA replication: The endoreduplication perspective. Experimental Cell Research 244, 372–378.
86. Greenlee, J. K., Rai, K. S. & Floyd, A. D. (1984). Intraspecific variation in nuclear DNA content in Collinsia verna Nutt. (Scrophulariaceae). Heredity 52, 235–242.
87. Gregory, T. R. (2000). Nucleotypic effects without nuclei: Genome size and erythrocyte size in mammals. Genome 43, 895–901.
88. Gregory, T. R. & Hebert, P. D. N. (1999). The modulation of DNA content: Proximate causes and ultimate consequences. Genome Research 9, 317–324.
89. Gregory, T. R., Hebert, P.D.N. & Kolasa, J. (2000). Evolutionary implications of the relationship between genome size and body size in flatworms and copepods. Heredity 84, 201–208.
90. Grime, J. P. & Mowforth, M. A. (1982). Variation in genome size - an ecological interpretation. Nature 299, 151–153.
91. Grime, J. P., Shacklock, J.M.L. & Band, S. R. (1985). Nuclear DNA contents, shoot phenology and species coexistence in a limestone grassland community. New Phytologist 100, 435–445.
92. Grishanin, A. K. (1995). Comparative electron microscopic study of chromosomes and interphase nuclei in cells of Cyclops kolensis (Copepoda, Crustacea) before and after chromatin diminution. Russian Journal of Developmental Biology 26, 153–158.
93. Grishanin, A. K., Brodskii, V. Ya. & Akif’ev, A. P. (1994). Somatic cells of Cyclops strenuus (Copepoda, Crustacea) lose about 90% of the genome during chromatin diminution. Doklady Biological Sciences 338, 505–506.
94. Grosset, L. & Odartchenko, N. (1975A). Duration of mitosis and separate mitotic phases compared to nuclear DNA content in erythroblasts of four vertebrates. Cell and Tissue Kinetics 8, 91–96.
95. Grosset, L. & Odartchenko, N. (1975B). Relationships between cell cycle duration, S-period and nuclear DNA content in erythroblasts of four vertebrate species. Cell and Tissue Kinetics 8, 81–90.
96. Gunge, N. & Nakatomi, Y. (1972). Genetic mechanisms of rare matings of the yeast Saccharomyces cerevisiae heterozygous for mating type. Genetics 70, 41–58.
97. Hagelberg, E., Goldman, N., Li’oa, P., Whelan, S., Schiefenho-Houvel, W., Clegg, J. B. & Bowden, D. K. (1999). Evidence for mitochondrialDNA recombination in a human population of island Melanesia. Proceedings of the Royal Society of London, Series B 266, 485–492.
98. Haugele, K. (1976). Prolongation of replication time after doublings of the DNA content of polytene chromosome bands of Chironomus. Chromosoma 55, 253–258.
99. Harvey, P.H. & Pagel, M. D. (1991). The Comparative Method in Evolutionary Biology. Oxford University Press, Oxford, UK.
100. Hertwig, R. (1903). Ü ber Korrelation von Zell- und Kerngrösse und ihre Bedeutung fÜr die geschechtliche Differenzierung und die Teilung der Zelle. Biologische Centralblat 23, 49–62.
101. Hieter, P. & Griffiths, T. (1999). Polyploidy - more is more or less. Science 285, 210–211.
102. Hinegardner, R. (1976). Evolution of genome size. In Molecular Evolution (ed. F. J. Ayala), pp. 179–199. Sinauer & Assoc., Sunderland, Mass.
103. Hinegardner, R. & Rosen, D. E. (1972). Cellular DNA content and the evolution of teleostean fishes. American Naturalist 106, 621–644.
104. Holm-Hansen, O. (1969). Algae: Amounts of DNA and organic carbon in single cells. Science 163, 87–88.
105. Horner, H. A. & Macgregor, H. C. (1983). C value and cell volume: Their significance in the evolution and development of amphibians. Journal of Cell Science 63, 135–146.
106. Hutchison, C. A., Peterson, S. N., Gill, S. R., Cline, R. T., White, O., Fraser, C. M., Smith, H.O. & Venter, J.G. (1999). Global transposon mutagenesis and a minimal Mycoplasma genome. Science 286, 2165–2169.
107. Ichikawa, S., Sparrow, A. H., Frankton, C., Nauman, A. F., Smith, E.B. & Pond, V. (1971). Chromosome number, volume and nuclear volume relationships in a polyploid series (2X-20X) of the genus Rumex. Canadian Journal of Genetics and Cytology 13, 842–863.
108. Jacob, F. (1982). The Possible and the Actual. Pantheon Books, New York.
109. Jain, H. K. (1980). Incidental DNA. Nature 288, 647–648.
110. Jockusch, E. L. (1997). An evolutionary correlate of genome size change in plethodontid salamanders. Proceedings of the Royal Society of LONDON, Series B 264, 597–604.
111. John, B. & Miklos, G. L. G. (1988). The Eukaryote Genome in Development and Evolution. Allen & UNWIN, London, UK.
112. John, P. C. L. & Jones, R. N. (1970). Molecular heterogeneity of soluble proteins and histones in relationship to the presence of B-chromosomes in rye. Experimental Cell Research 63, 271–276.
113. Johnston, J. S., Jensen, A., Czeschin, D.G. & Price, H. J. (1996). Environmentally induced nuclear 2C DNA content instability in Helianthus annuus (Asteraceae). American Journal of Botany 83, 1113–1120.
114. Jones, R.N. & Brown, L. M. (1976). Chromosome evolution and DNA variation in Crepis. Heredity 36, 91–104.
115. Juan, C. & Petitpierre, E. (1991). Evolution of genome size in darkling beetles (Tenebrionidae, Coleoptera). Genome 34, 169–173.
116. Kamel, S., Marsden, J. E. & Pough, F. H. (1985). Diploid and tetraploid grey treefrogs (Hyla chrysoscelis and Hyla versicolor) have similar metabolic rates. Comparative Biochemistry and Physiology 82A, 217–220.
117. Karp, A., Rees, H. & Jewell, A. W. (1982). The effects of nucleotype and genotype upon pollen grain development in Hyacinth and Scilla. Heredity 48, 251–261.
118. Karpen, G. H. (1994). Position-effect variegation and the new biology of heterochromatin. Current Opinion in Genetics & Development 4, 281–291.
119. Kearsey, S. E., Labib, K. & Maiorano, D. (1996). Cell cycle control of eukaryotic DNA replication. Current Opinion in Genetics & Development 6, 208–214.
120. Kidwell, M. G. & Lisch, D. R. (2000). Transposable elements and host genome evolution. Trends in Ecology and Evolution 15, 95–99.
121. Kubota, S., Nakai, Y., Sato, N., Kuro-o, M. & Kohno, S. (1994). Chromosome elimination in Northeast Pacific hagfish, Eptatretus stoutii (Cyclostomata, Agnatha) Journal of Heredity 85, 413–415.
122. Kubrakiewicz, J. & Bilinski, S. M. (1995). Extrachromosomal amplification of rDNA in oocytes of Hemerobius spp. (Insecta, Neuroptera). Chromosoma 103, 606–612.
123. Kuldau, G. A., Tsai, H.-F. & Schardl, C. L. (1999). Genome sizes of EpichloeX species and anamorphic hybrids. Mycologia 91, 776–792.
124. Kuramoto, M. (1981). Relationships between number, size and shape of red blood cells in amphibians. Comparative Biochemistry and Physiology 69A, 771–775.
125. Lang, F. & Waldegger, S. (1997). Regulating cell volume. American Scientist 85, 456–463.
126. Lawrence, M. E. (1985). Senecio L. (Asteraceae) in Australia: Nuclear DNA amounts. Australian Journal of Botany 33, 221–232.
127. Leatherwood, J. (1998). Emerging mechanisms of eukaryotic DNA replication initiation. Current Opinion in Cell Biology 10, 742–748.
128. Lee, M. S. & Silver, P. A. (1997). Rna movement between the nucleus and the cytoplasm. Current Opinion in Genetics & Development 7, 212–219.
129. Li, W.-H. (1997). Molecular Evolution. Sinauer & Assoc., Sunderland, Mass.
130. Licht, L.E. & Bogart, J. P. (1987). Comparative size of epidermal cell nuclei from shed skin of diploid, triploid and tetraploid salamanders (Genus Ambystoma). Copeia 1987, 284–290.
131. Licht, L.E. & Bogart, J. P. (1990). Comparative rates of oxygen consumption and water loss in diploid and polyploid salamanders (genus Ambystoma). Comparative Biochemistry and Physiology 97A, 569–572.
132. Licht, L.E. & Lowcock, L. A. (1991). Genome size and metabolic rate in salamanders. Comparataive Biochemistry and Physiology 100B, 83–92.
133. Lockwood, S.F. & Bickham, J. W. (1992). Genome size in Beaufort Sea coastal assemblages of Arctic ciscoes. Transactions of the American Fisheries Society 121, 13–20.
134. Lozovskaya, E. R., Hartl, D.L. & Petrov, D. A. (1995). Genomic regulation of transposable elements in Drosophila. Current Opinion in Genetics & Development 5, 768–773.
135. Macaulay, V., Richards, M. & Sykes, B. (1999). Mitochondrial DNA recombination - no need to panic. Proceedings of the Royal Society of London, Series B 266, 2037–2039.
136. Manfredi Romanini, M. G. (1973). The DNA nuclear content and the evolution of vertebrates. In Cytotaxonomy and Vertebrate Evolution (ed. A. B. Chiarelli and E. Capanna), pp. 39–81. Academic Press, New York.
137. Marshall, W. F., Fung, J. C. & Sedat, J. W. (1997). Deconstructing the nucleus: Global architechture from local interactions. Current Opinion in Genetics & Development 7, 259–263.
138. Martin, C.C. & Gordon, R. (1995). Differentiation trees, a junk DNA molecular clock and the evolution of neoteny in salamanders. Journal of Evolutionary Biology 8, 339–354.
139. Martin, P. G. (1966). Variation in the amounts of nucleic acids in the cells of different species of higher plants. Experimental Cell Research 44, 84–94.
140. Maynard Smith, J. & Szathma Ry, E. (1995). The Major Transitions in Evolution. Oxford University Press, Oxford, UK.
141. Mayr, E. (1983). How to carry out the adaptationist program American Naturalist 121, 324–334.
142. Mclaren, I. A. & Marcogliese, S. J. (1983). Similar nucleus numbers among copepods. Canadian Journal of Zoology 61, 721–724.
143. Meleragno, J. E., Mehrotra, B. & Coleman, A. W. (1993). Relationship between endopolyploidy and cell size in epidermal tissue of Arabidopsis. Plant Cell 5, 1661–1668.
144. Minelli, S., Moscariello, P., Ceccarelli, M. & Cionini, P. G. (1996). Nucleotype and phenotype in Vicia faba. Heredity 76, 524–530.
145. Mirsky, A.E. & Ris, H. (1951). The desoxyribonucleic acid content of animal cells and its evolutionary significance. Journal of General Physiology 34, 451–462.
146. Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S.C. & Thomas, G. (1999). Drosophila S6 kinase: A regulator of cell size. Science 285, 2126–2129.
147. Morescalchi, A. (1975). Chromosome evolution in the caudate Amphibia. Evolutionary Biology 8, 339–387.
148. Mowforth, M.A. & Grime, J. P. (1989). Intra-population variation in nuclear DNA amount, cell size and growth rate in Poa annua L. Functional Ecology 3, 289–295.
149. Müuntzing, A. & Akdik, S. (1948). The effect on cell size of accessory chromosomes in rye. Hereditas 34, 248–250.
150. Nagele, R., Freeman, T., Mcmorrow, L. & Lee, H.Y. (1995). Precise spatial positioning of chromosomes during prometaphase: Evidence for chromosomal order. Science 270, 1831–1835.
151. Nagl, W. (1974). Mitotic cycle time in perennial and annual plants with various amounts of DNA and heterochromatin. Developmental Biology 39, 342–346.
152. Nagl, W. (1976). Dna endoreduplication and polyteny understood as evolutionary strategies. Nature 261, 614–615.
153. Licht, L.E. & Lowcock, L. A. (1991). Genome size and metabolic rate in salamanders. Comparataive Biochemistry and Physiology 100B, 83–92.
154. Lockwood, S.F. & Bickham, J. W. (1992). Genome size in Beaufort Sea coastal assemblages of Arctic ciscoes. Transactions of the American Fisheries Society 121, 13–20.
155. Lozovskaya, E. R., Hartl, D.L. & Petrov, D. A. (1995). Genomic regulation of transposable elements in Drosophila. Current Opinion in Genetics & Development 5, 768–773.
156. Macaulay, V., Richards, M. & Sykes, B. (1999). Mitochondrial DNA recombination - no need to panic. Proceedings of the Royal Society of London, Series B 266, 2037–2039.
157. Manfredi Romanini, M. G. (1973). The DNA nuclear content and the evolution of vertebrates. In Cytotaxonomy and Vertebrate Evolution (ed. A. B. Chiarelli and E. Capanna), pp. 39–81. Academic Press, New York.
158. Marshall, W. F., Fung, J. C. & Sedat, J. W. (1997). Deconstructing the nucleus: Global architechture from local interactions. Current Opinion in Genetics & Development 7, 259–263.
159. Martin, C.C. & Gordon, R. (1995). Differentiation trees, a junk DNA molecular clock and the evolution of neoteny in salamanders. Journal of Evolutionary Biology 8, 339–354.
160. Martin, P. G. (1966). Variation in the amounts of nucleic acids in the cells of different species of higher plants. Experimental Cell Research 44, 84–94.
161. Maynard Smith, J. & Szathmáry, E. (1995). The Major Transitions in Evolution. Oxford University Press, Oxford, UK.
162. Mayr, E. (1983). How to carry out the adaptationist program American Naturalist 121, 324–334.
163. Mclaren, I. A. & Marcogliese, S. J. (1983). Similar nucleus numbers among copepods. Canadian Journal of Zoology 61, 721–724.
164. Meleragno, J. E., Mehrotra, B. & Coleman, A. W. (1993). Relationship between endopolyploidy and cell size in epidermal tissue of Arabidopsis. Plant Cell 5, 1661–1668.
165. Minelli, S., Moscariello, P., Ceccarelli, M. & Cionini, P. G. (1996). Nucleotype and phenotype in Vicia faba. Heredity 76, 524–530.
166. Mirsky, A.E. & Ris, H. (1951). The desoxyribonucleic acid content of animal cells and its evolutionary significance. Journal of General Physiology 34, 451–462.
167. Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S.C. & Thomas, G. (1999). Drosophila S6 kinase: A regulator of cell size. Science 285, 2126–2129.
168. Morescalchi, A. (1975). Chromosome evolution in the caudate Amphibia. Evolutionary Biology 8, 339–387.
169. Mowforth, M.A. & Grime, J. P. (1989). Intra-population variation in nuclear DNA amount, cell size and growth rate in Poa annua L. Functional Ecology 3, 289–295.
170. Müntzing, A. & Akdik, S. (1948). The effect on cell size of accessory chromosomes in rye. Hereditas 34, 248–250.
171. Nagele, R., Freeman, T., Mcmorrow, L. & Lee, H.Y. (1995). Precise spatial positioning of chromosomes during prometaphase: Evidence for chromosomal order. Science 270, 1831–1835.
172. Nagl, W. (1974). Mitotic cycle time in perennial and annual plants with various amounts of DNA and heterochromatin. Developmental Biology 39, 342–346.
173. Nagl, W. (1976). Dna endoreduplication and polyteny understood as evolutionary strategies. Nature 261, 614–615.
174. Nagl, W. (1978). Endopolyploidy and Polyteny in Differentiation and Evolution. North-Holland, Amsterdam.
175. Nakielny, S. & Dreyfuss, G. (1997). Nuclear export of proteins and RNAs. Current Opinion in Cell Biology 9, 420–429.
176. Nardi, I., Batistoni, R., Marracci, S. & Lanza, B. (1999). Repetitive DNA components of the large Hydromantes genome: Phylogenetic and molecular aspects. Herpetologica 55, 131–139.
177. Natali, L., Cavallini, A., Cionini, G., Sassoli, O., Cionini, P. G. & Durante, M. (1993). Nuclear DNA changes within Helianthus annuus L.: Changes within single progenies and their relationships with plant development. Theoretical and Applied Genetics 85, 506–512.
178. Neufeld, T. P. & Edgar, B. A. (1998). Connections between growth and the cell cycle. Current Opinion in Cell Biology 10, 784–790.
179. Nurse, P. (1985). The genetic control of cell volume. In The Evolution of Genome Size (ed. T. Cavalier-Smith), pp. 185–196. John Wiley & Sons, Chichester, UK.
180. Ohno, S. (1970). Evolution by Gene Duplication. Springer-Verlag, New York.
181. Ohno, S. (1972). So much ‘junk’ DNA in our genome. In Evolution of Genetic Systems (ed. H. H. Smith), pp. 366–370. Gordon & Breach, New York.
182. Ohri, D. (1998). Genome size and plant systematics. Annals of Botany 82 (Supplement A), 75–83.
183. Ohri, D., Fritsch, M. & Hanelt, P. (1998). Evolution of genome size in Allium (Alliaceae). Plant Systematics and Evolution 210, 57–86.
184. 1 in mammalian fibroblasts. Science 259, 1908–1912.
185. Olmo, E. (1983). Nucleotype and cell size in vertebrates: A review. Basic and Applied Histochemistry 27, 227–256.
186. Olmo, E. & Morescalchi, A. (1975). Evolution of the genome and cell sizes in salamanders. Experientia 31, 804–806.
187. Olmo, E. & Morescalchi, A. (1978). Genome and cell size in frogs: A comparison with salamanders. Experientia 34, 44–46.
188. Orgel, L.E. & Crick, F. H. C. (1980). Selfish DNA: The ultimate parasite. Nature 284, 604–607.
189. Orgel, L. E., Crick, F.H.C. & Sapienza, C. (1980). Selfish DNA. Nature 288, 645–646.
190. ÖStergren, G. (1945). Parasitic nature of extra fragment chromosomes. Botan. Notiser 2, 157–163.
191. Pagel, M. & Johnstone, R. A. (1992). Variation across species in the size of the nuclear genome supports the junk-DNA explanation for the C-value paradox. Proceedings of the Royal Society of London, Series B 249, 119–124.
192. Palmer, M. & Petitpierre, E. (1996). Relationship of genome size to body size in Phylan semicostatus (Coleoptera: Tenebrionidae). Annals of the Entomological Society of America 89, 221–225.
193. Peters, R. H. (1983). Ecological Implictions of Body Size. Cambridge University Press, Cambridge, UK.
194. Petitpierre, E., Segarra, C. & Juan, C. (1993). Genome size and chromosomal evolution in leaf beetles (Coleoptera, Chrysomelidae). Hereditas 119, 1–6.
195. Polymenis, M. & Schmidt, E. V. (1999). Coordination of cell growth with cell division. Current Opinion in Genetics & Development 9, 76–80.
196. Price, H. J. (1988). Nuclear DNA content variation within angiosperm species. Evolutionary Trends in Plants 2, 53–60.
197. Price, H. J. & Bachmann, K. (1976). Mitotic cycle time and DNA content in annual and perennial Microseridinae (Compositae, Cichoriaceae). Plant Systematics and Evolution 126, 323–330.
198. Price, H. J. & Johnston, J. S. (1996). Influence of light on DNA content of Helianthus annuus Linnaeus. Proceedings of the National Academy of Sciences of the USA 93, 11264–11267.
199. Price, H. J., Morgan, P.W. & Johnston, J. S. (1998). Environmentally correlated variation in 2C nuclear DNA content measurements in Helianthus annuus L. Annals of Botany 82 (Supplement A), 95–98.
200. Price, H. J., Sparrow, A.H. & Nauman, A. F. (1973). Correlations between nuclear volume, cell volume and DNA content in meristematic cells of herbaceous angiosperms. Experientia 29, 1028–1029.
201. Primmer, C. R., Raudsepp, T., Chowdhary, B. P., Møller, A. P., & Ellegren, H. (1997). Low frequency of microsatellites in the avian genome. Genome Research 7, 471–482.
202. Pritchard, D.K. & Schubiger, G. (1996). Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio. Genes & Development 10, 1131–1142.
203. Quelle, D. E., Ashmun, R. A., Shurtleff, S. A., Kato, J. Y., Bar-sagi, D., Roussel, M.F. & Sherr, C. J. (1993). Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes and Development 7, 1559–1571.
204. Randolph, L. F. (1941). Genetic characteristics of the Bchromosomes in maize. Genetics 26, 608–631.
205. Rayburn, A. L., Price, H. J., Smith, J.D. & Gold, J.R. (1985). C-band heterochromatin and DNA content in Zea mays. American Journal of Botany 72, 1610–1617.
206. Reeder, R. H. (1999). Regulation of RNA polymerase I transcription in yeast and vertebrates. Progress in Nucleic Acid Research and Molecular Biology 62, 293–327.
207. Rees, H. & Jones, R. N. (1972). The origin of the wide species variation in nuclear DNA content. International Review of Cytology 32, 53–92.
208. Rees, H., Jenkins, G., Seal, A. G. & Hutchinson, J. (1982). Assays of the phenotypic effects of changes in DNA amounts. In Genome Evolution (ed. G. A. Dover & R. B. Flavell), pp. 287–297. Academic Press, New York.
209. Renzaglia, K. S., Rasch, E.M. & Pike, L. M. (1995). Estimates of nuclear DNA content in bryophyte sperm cells: Phylogenetic considerations. American Journal of Botany 82, 18–25.
210. Rosato, M., Chiavarno, A. M., Naranjo, C. A. & Poggio, L. (1997). B chromosomes in native races of maize from Argentina. Ii. Genome size and altitude. Maize Genetics Cooperation Newsletter 71, 47–48.
211. Rosato, M., Chiavarno, A. M., Naranjo, C. A., Hernandez, J. C. & Poggio, L. (1998). Genome size and numerical polymorphism for the B chromosome in races of maize (Zea mays ssp. Mays, Poaceae). American Journal of Botany 85, 168–174.
212. Roth, G., Blanke, J. & Wake, D. B. (1994). Cell size predicts morphological complexity in the brains of frogs and salamanders. Proceedings of the National Academy of Sciences of the USA 91, 4796–4800.
213. Roth, G., Nishikawa, K.C. & Wake, D. B. (1997). Genome size, secondary simplification and the evolution of the brain in salamanders. Brain, Behavior and Evolution 50, 50–59.
214. Sachsenmaier, W., Remy, U. & Plattner-Schobel, R. (1972). Initiation of synchronous mitosis in Physarum polycephalum. A model of the control of cell division in eukaryotes. Experimental Cell Research 73, 41–48.
215. Sessions, S.K. & Larson, A. (1987). Developmental correlates of genome size in plethodontid salamanders and their implications for genome evolution. Evolution 41, 1239–1251.
216. Shuter, B. J., Thomas, J. E., Taylor, W.D. & Zimmerman, A. M. (1983). Phenotypic correlates of genomic DNA content in unicellular eukaryotes and other cells. American Naturalist 122, 26–44.
217. Smith, H. M. (1925). Cell size and metabolic activity in Amphibia. Biological Bulletin 48, 347–378.
218. Sompayrac, L. & Maaløe, O. (1973). Autorepressor model for control of DNA replication. Nature, New Biology 241, 133–135.
219. Sparrow, A. H., Price, H. J. & Underbink, A. G. (1972). A survey of DNA content per cell and per chromosome of prokaryotic and eukaryotic organisms: Some evolutionary considerations. In Evolution of Genetic Systems (ed. H. H. Smith), pp. 451–494. Gordon & Breach, New York.
220. Stebbins, G. L. (1947). Types of polyploids: Their classification and significance. Advances in Genetics 1, 403–429.
221. Stebbins, G. L. (1971). Chromosomal Evolution in Higher Plants. Edward Arnold, London, UK.
222. Strange, K. (1994). Are all cell volume changes the same News in Physiological Science 9, 223–228.
223. Strasburger, E. (1893). Über die Wirkungssphäre der Kerne und die Zellgrösse. Histol. Beitr. 5, 97–124.
224. Summers, J. C., Trais, L., Lajvardi, R., Hergan, D., Buechler, R., Chang, H., Peñta-Rasgado, C. & Rasgado-Flores, H. (1997). Role of concentration and size of intracellular macromolecules in cell volume regulation. American Journal of Physiology-Cell Physiology 42, C360–C370.
225. Sun, H.B. & Yokota, H. (1999). Correlated positioning of homologous chromosomes in daughter fibroblast cells. Chromosome Research 7, 603–610.
226. Suzuki, M. G., Shimada, T., Yokoyama, T. & Kobayashi, M. (1999). The influence of triploidy on gene expression in the silkworm, Bombyx mori. Heredity 82, 661–667.
227. Swift, H. (1950A). The constancy of desoxyribose nucleic acid in plant nuclei. Proceedings of the National Academy of Sciences of the USA 36, 643–654.
228. Swift, H. (1950B). The desoxyribose nucleic acid content of animal nuclei. Physiological Zoology 23, 169–198.
229. Szarski, H. (1983). Cell size and the concept of wasteful and frugal evolutionary strategies. Journal of Theoretical Biology 105, 201–209.
230. Thomas, C. A. (1971). The genetic organization of chromosomes. Annual Review of Genetics 5, 237–256.
231. Thomson, K. S. (1972). An attempt to reconstruct evolutionary changes in the cellular DNA content of lungfish. Journal of Experimental Zoology 180, 363–372.
232. Thomson, K. S. & Muraszko, K. (1978). Estimation of cell size and DNA content in fossil fishes and amphibians. Journal of Experimental Zoology 205, 315–320.
233. Tiersch, T.R. & Wachtel, S. S. (1991). On the evolution of genome size of birds. Journal of Heredity 82, 363–368.
234. Tito, C. M., Poggio, L. & Naranjo, C. A. (1991). Cytogenetic studies in the genus Zea. 3. Dna content and heterochromatin in species and hybrids. Theoretical and Applied Genetics 83, 58–64.
235. Traas, J., Hülskamp, M., Gendreau, E. & Höfte, H. (1998). Endoreduplication and development: Rule without dividing Current Opinion in Plant Biology 1, 498–503.
236. Trombetta, V. V. (1942). The cytonuclear ratio. Botanical Reviews 8, 317–336.
237. Van Den Bussche, R. A., Longmire, J.L. & Baker, R. J. (1995). How bats achieve a small C-value: Frequency of repetitive DNA in Macrotus. Mammalian Genome 6, 521–525.
238. Van Munster, E. B., Stap, J., Hoebe, R. A., Te Meerman, G. J. & Aten, J. A. (1999). Difference in volume of X-and Y-chromosome-bearing bovine sperm heads matches difference in DNA content. Cytometry 35, 125–128.
239. Van’Thof, J. (1965). Relationships between mitotic cycle duration, S period duration and the average rate of DNA synthesis in the root meristem cells of several plants. Experimental Cell Research 39, 48–58.
240. Van’t Hof, J. & Sparrow, A. H. (1963). A relationship between DNA content, nuclear volume and minimum mitotic cycle time. Proceedings of the National Academy of Sciences of the USA 49, 897–902.
241. Vendrely, R. (1955). The deoxyribonucleic acid content of the nucleus. In The Nucleic Acids, Vol. Ii (ed. E. Chagraff & J. N. Davidson), pp. 155–180. Academic Press, New York.
242. Vialli, M. (1957). Volume et contenu en AND par noyau. Experimental Cell Research Supplement 4, 284–293.
243. Vignali, R. & Nardi, I. (1996). Unusual features of the urodele genome: Do they have a role in evolution and development International Journal of Developmental Biology 40, 637–643.
244. Vinogradov, A. E. (1998). Buffering: A possible passivehomeostasis role for redundant DNA. Journal of Theoretical Biology 193, 197–199.
245. Vinogradov, A. E. (1999). Genome in toto. Genome 42, 361–362.
246. Vinogradov, A. E. (2000). Larger genomes for molluskan land pioneers. Genome 43, 211–212.
247. Von Sternberg, R. M., Novick, G. E., Gao, G. P. & Herrera, R. J. (1992). Genome canalization: The coevolution of transposable and interspersed repetitive elements with single copy DNA. Genetica 86, 215–246.
248. Wake, D.B. & Marks, S. B. (1993). Development and evolution of plethodontid salamanders: A review of prior studies and a prospectus for future research. Herpetologica 49, 194–203.
249. Waldegger, S. & Lang, F. (1998). Cell volume and gene expression. Journal of Membrane Biology 162, 95–100.
250. Waldegger, S., Matskevitch, J., Busch, G.L. & Lang, F. (1998). Introduction to cell volume regulatory mechanisms. In Cell Volume Regulation (ed. F. Lang), pp. 1–7. Contrib. Nephrol. Basel. Karger, Vol 123.
251. Walker, L. I., Spotorno, A. E. & Sans, J. (1991). Genome size variation and its phenotypic consequences in Phyllotis rodents. Hereditas 115, 99–107.
252. Wallrath, L. L. (1998). Unfolding the mysteries of heterochromatin. Current Opinion in Genetics & Development 8, 147–153.
253. Wettstein, F. (1937). Experimentelle Untersuchungen zum Artbildungs-problem, I. Zell grossenregulation und Fertilwerden einer polyploiden Bryum Sippe. Zeitsch. Ind. Abst. Vererb. 74, 34–53.
254. Whitmarsh, A. J. & Davis, R. J. (2000). A central control for cell growth. Nature 403, 255–256.
255. Wijnen, H. & Futcher, B. (1999). Genetic analysis of the shared role of CLN3 and BCK2 at the G"-S transition in Saccharomyces cerevisiae. Genetics 153, 1131–1143.
256. Wilson, E. B. (1925). The Cell in Development and Heredity. Macmillan, New York.
257. Yan, H., Papadopoulos, N., Marra, G., Perrera, C., Jiricny, J., Boland, C. R., Lynch, H. T., Chadwick, R. B., De la Chapelle, A., Berg, K., Eshleman, J. R., Yuan, W., Markowitz, S., Laken, S. J., Lengauer, C., Kinzler, K. W., Vogelstein, B. (2000). Conversion of diploidy to haploidy. Nature 403, 723–724.
258. Ycas, M., Sugita, M. & Bensam, A. (1965). A model of cell size regulation. Journal of Theoretical Biology 9, 444–470.
259. Zeyl, C. & Bell, G. (1996). Symbiotic DNA in eukaryotic genomes. Trends in Ecology and Evolution 11, 10–15.
260. Zünd, P. & Lebek, G. (1980). Generation time-prolonging R plasmids: Correlation between increases in the generation time of Escherichia coli caused by R plasmids and their molecular size. Plasmid 3, 65–69.